EIPA, A macropinocytosis blocking agent, inhibits Siniperca chuatsi rhabdovirus infection in vitro and in vivo
文献类型： 外文期刊
作者： Liang, Hongru 1 ; Luo, Xia 1 ; Lin, Qiang 1 ; Fu, Xiaozhe 1 ; Niu, Yinjie 1 ; Ma, Baofu 1 ; Li, Ningqiu 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Fishery Drug Dev,Minist Agr & Rural Affair, Guangdong Prov Key Lab Aquat Anim Immunol & Sustai, Guangzhou 510380, Peoples R China
关键词： SCRV; EIPA; Inhibit; Endocytosis
期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.5； 五年影响因子：3.6 ）
ISSN： 0882-4010
年卷期： 2025 年 206 卷
页码：
收录情况： SCI
摘要： Siniperca chuatsi rhabdovirus (SCRV) is a highly pathogenic virus that infects Siniperca chuatsi and causes cumulative mortality rates exceeding 90 % in fish fry. Until now, there have been no specific treatments for this virus. In this study, four different chemical inhibitors were evaluated for their ability to inhibit SCRV. Only ethylisopropyl amiloride (EIPA), a macropinocytosis inhibitor, effectively inhibited SCRV replication in CPB cells without cytotoxicity. Further studies indicated that EIPA inhibited an early post-entry step of viral infection. To evaluate the effect in vivo, largemouth bass (Micropterus salmoides) were infected with SCRV and fed with EIPA. The results showed that EIPA effectively inhibited SCRV infection in vitro and in vivo, suggesting its potential applicability as a therapeutic agent for SCRV treatment.
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