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Tissue factor pathway inhibitors disrupt structures of rhabdovirus/ ranairidovirus and inhibit viral infection in Chinese perch, Siniperca chuatsi

文献类型： 外文期刊

作者： Ma, Baofu 1 ; Li, Jingkang 1 ; Zhang, Min 4 ; Fu, Xiaozhe 1 ; Liang, Hongru 1 ; Niu, Yinjie 1 ; Lin, Qiang 1 ; Luo, Xia 1 ; Liu, Lihui 1 ; Su, Jianguo 3 ; Zhou, Jin 2 ; Li, Ningqiu 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fishery Res Inst, Key Lab Fishery Drug Dev, Guangdong Prov Key Lab Aquat Anim Immune & Sustain, Guangzhou 510380, Peoples R China

2.Tsinghua Univ, Shenzhen Int Grad Sch, Shenzhen 518055, Peoples R China

3.Huazhong Agr Univ, Coll Fishies, Wuhan 430070, Peoples R China

4.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Peoples R China

关键词： Viral diseases; Aquaculture industry; Peptides; Antiviral activity

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2024 年 149 卷

页码：

收录情况： SCI

摘要： Viral diseases have caused great economic losses to the aquaculture industry. However, there are currently no specific drugs to treat these diseases. Herein, we utilized Siniperca chuatsi as an experimental model, and successfully extracted two tissue factor pathway inhibitors (TFPIs) that were highly distributed in different tissues. We then designed four novel peptides based on the TFPIs, named TS20, TS25, TS16, and TS30. Among them, TS25 and TS30 showed good biosafety and high antiviral activity. Further studies showed that TS25 and TS30 exerted their antiviral functions by preventing viruses from invading Chinese perch brain (CPB) cells and disrupting Siniperca chuatsi rhabdovirus (SCRV)/Siniperca chuatsi ranairidovirus (SCRIV) viral structures. Additionally, compared with the control group, TS25 and TS30 could significantly reduce the mortality of Siniperca chuatsi, the relative protection rates of TS25 against SCRV and SCRIV were 71.25 % and 53.85 % respectively, and the relative protection rate of TS30 against SCRIV was 69.23 %, indicating that they also had significant antiviral activity in vivo. This study provided an approach for designing peptides with biosafety and antiviral activity based on host proteins, which had potential applications in the prevention and treatment of viral diseases.

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