Hypoxia tolerance in fish depends on catabolic preference between lipids and carbohydrates
文献类型： 外文期刊
作者： Ma, Qiang 1 ; Luo, Yuan 1 ; Zhong, Jia 3 ; Limbu, Samwel Mchele 4 ; Li, Ling-Yu 1 ; Chen, Li-Qiao 1 ; Qiao, Fang 1 ; Zhang, Mei-Ling 1 ; Lin, Qiang 3 ; Du, Zhen-Yu 1 ;
作者机构： 1.East China Normal Univ, Sch Life Sci, LANEH, Shanghai 200241, Peoples R China
2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China
3.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bio Resources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
4.Univ Dar Es Salaam, Sch Aquat Sci & Fisheries Technol, Dar Es Salaam 60091, Tanzania
关键词： Hypoxia tolerance; Catabolic preference; Lipid; Carbohydrate; Oxidative damage
期刊名称：ZOOLOGICAL RESEARCH （ 影响因子：4.9； 五年影响因子：4.6 ）
ISSN： 2095-8137
年卷期： 2023 年 44 卷 5 期
页码：
收录情况： SCI
摘要： Hypoxia is a common environmental stress factor in aquatic organisms, which varies among fish species. However, the mechanisms underlying the ability of fish species to tolerate hypoxia are not well known. Here, we showed that hypoxia response in different fish species was affected by lipid catabolism and preference for lipid or carbohydrate energy sources. Activation of biochemical lipid catabolism through peroxisome proliferator-activated receptor alpha (Ppar alpha) or increasing mitochondrial fat oxidation in tilapia decreased tolerance to acute hypoxia by increasing oxygen consumption and oxidative damage and reducing carbohydrate catabolism as an energy source. Conversely, lipid catabolism inhibition by suppressing entry of lipids into mitochondria in tilapia or individually knocking out three key genes of lipid catabolism in zebrafish increased tolerance to acute hypoxia by decreasing oxygen consumption and oxidative damage and promoting carbohydrate catabolism. However, anaerobic glycolysis suppression eliminated lipid catabolism inhibition-promoted hypoxia tolerance in adipose triglyceride lipase (atgl) mutant zebrafish. Using 14 fish species with different trophic levels and taxonomic status, the fish preferentially using lipids for energy were more intolerant to acute hypoxia than those preferentially using carbohydrates. Our study shows that hypoxia tolerance in fish depends on catabolic preference for lipids or carbohydrates, which can be modified by regulating lipid catabolism.
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