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Towards a Safer Future: Enhancing Vaccine Development to Combat Animal Coronaviruses

文献类型： 外文期刊

作者： Si, Fusheng 1 ; Yu, Ruisong 1 ; Dong, Shijuan 1 ; Chen, Bingqing 1 ; Li, Chunhua 1 ; Song, Shuai 2 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Med, Shanghai Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China

2.Guangdong Acad Agr Sci, Sci Observat & Expt Stn Vet Drugs & Diagnost Tech, Inst Anim Hlth, Minist Agr & Rural Affairs, Guangzhou 510640, Peoples R China

3.Key Lab Livestock Dis Prevent Guangdong Prov, Guangzhou 510640, Peoples R China

关键词： one health; animal coronaviruses; vaccine; platforms and strategies; targets and efficacy

期刊名称：VACCINES （ 影响因子：7.8； 五年影响因子：7.4 ）

ISSN：

年卷期： 2024 年 12 卷 3 期

页码：

收录情况： SCI

摘要： Coronaviruses (CoVs) are a large class of positively stranded RNA viruses that pose a significant threat to public health, livestock farming, and wild animals. These viruses have the ability to cross species barriers and cause devastating epidemics. Animals are considered to be intermediate hosts for many coronaviruses, and many animal coronaviruses also have the potential for cross-species transmission to humans. Therefore, controlling the epidemic transmission of animal coronaviruses is of great importance to human health. Vaccination programs have proven to be effective in controlling coronaviruses infections, offering a cost-effective approach to reducing morbidity and mortality, so the re-emergence of lethal coronaviruses emphasizes the urgent need for the development of effective vaccines. In this regard, we explore the progress in animal coronavirus vaccine development, covering the latest taxonomy of the main animal coronaviruses, spillover events, diverse vaccine development platforms, potential main targets for animal coronavirus vaccine development, and primary challenges facing animal coronavirus vaccines. We emphasize the urgent need to create a "dual-effect" vaccine capable of eliciting both cellular and humoral immune responses. The goal is to highlight the contributions of veterinary scientists in this field and emphasize the importance of interdisciplinary collaboration between the veterinary and medical communities. By promoting communication and cooperation, we can enhance the development of novel and super vaccines to combat human and animal coronavirus infections in the future.

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