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Comparative metabolomics analysis investigating the impact of melatonin-enriched diet on energy metabolism in the crayfish, Cherax destructor

文献类型： 外文期刊

作者： Yang, Ying 1 ; Tian, Jiangtao 1 ; Xu, Wenyue 1 ; Ping, Cuobaima 1 ; Du, Xinglin 1 ; Ye, Yucong 1 ; Zhu, Bihong 1 ; Huang, Yizhou 1 ; Li, Yiming 2 ; Jiang, Qichen 3 ; Zhao, Yunlong 1 ;

作者机构： 1.East China Normal Univ, Sch Life Sci, 500 Dongchuan Rd, Shanghai 200241, Peoples R China

2.Chinese Acad Fisheries Sci, Fishery Machinery & Instrument Res Inst, Shanghai 200092, Peoples R China

3.Freshwater Fisheries Res Inst Jiangsu Prov, 79 Chating East St, Nanjing 210017, Peoples R China

4.East China Normal Univ, State Key Lab Estuarine & Coastal Res, Shanghai 200241, Peoples R China

关键词： Melatonin; Metabolomics; Energy metabolism; Cherax destructor; Gene expression

期刊名称：JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY （ 影响因子：2.0； 五年影响因子：2.2 ）

ISSN： 0174-1578

年卷期： 2023 年 193 卷 6 期

页码：

收录情况： SCI

摘要： Melatonin is a multifunctional bioactive molecule present in almost all organisms and has been gradually used in the aquaculture industry in recent years. Energy metabolism is an essential process for individuals to maintain their life activities; however, the process through which melatonin regulates energy metabolism in aquatic animals remains unclear. The present study aimed to conduct a comprehensive analysis of the regulatory mechanism of melatonin for energy metabolism in Cherax destructor by combining metabolomics analysis with the detection of the key substance content, enzymatic activity, and gene expression levels in the energy metabolism process after culturing with dietary melatonin supplementation for 8 weeks. Our results showed that dietary melatonin increased the content of glycogen, triglycerides, and free fatty acids; decreased lactate levels; and promoted the enzymatic activity of pyruvate kinase (PK), malate dehydrogenase (MDH), and acetyl-CoA carboxylase. The results of gene expression analysis showed that dietary melatonin also increased the expression levels of hexokinase, PK, MDH, lactate dehydrogenase, lipase, and fatty acid synthase genes. The results of metabolomics analysis showed that differentially expressed metabolites were significantly enriched in lysine degradation and glycerophospholipid metabolism. In conclusion, our study demonstrates that dietary melatonin increased oxidative phosphorylation, improved glucose utilization, and promoted storage of glycogen and lipids in C. destructor. These lipids are used not only for energy storage but also to maintain the structure and function of cell membranes. Our results further add to the understanding of the mechanisms of energy regulation by melatonin in crustaceans.

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