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Unraveling the stress response: How low temperature and nanoparticles impact the chinese mitten crab (Eriocheir sinensis)

文献类型： 外文期刊

作者： Zhou, Zihan 1 ; Tian, Jian 2 ; Si, Qin 4 ; Tay, Yi Juin 3 ; Han, Mingming 3 ; Jiang, Qichen 2 ; Wang, Lanmei 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Minist Agr & Rural Affairs, Key Lab Freshwater Fisheries & Germplasm Resources, Freshwater Fisheries Res Ctr, Wuxi 214081, Peoples R China

2.Freshwater Fisheries Res Inst Jiangsu Prov, Nanjing 210017, Peoples R China

3.Univ Sains Malaysia, Ctr Marine & Coastal Studies, Minden 11800, Penang, Malaysia

4.Jiangsu Maritime Inst, 309 Gezhi Rd, Nanjing 211100, Jiangsu, Peoples R China

关键词： Eriocheir sinensis; Nanoplastics; PI3K-Akt-FoxO; Multi-omics

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：11.3； 五年影响因子：12.4 ）

ISSN： 0304-3894

年卷期： 2025 年 494 卷

页码：

收录情况： SCI

摘要： The Chinese mitten crab (Eriocheir sinensis) is a freshwater crustacean of considerable economic significance. To elucidate its physiological regulatory mechanisms under environmental stressors, we examined responses to low temperature (10 degrees C), ambient temperature (25 degrees C), and polystyrene nanoparticles (PS-NPs; 0, 1, and 10 mg/L) over a 28-day period. Exposure to these stressors led to a marked increase in glutathione peroxidase (GSH-Px) and lysozyme (LZM) activity, alongside a notable suppression of superoxide dismutase (SOD). Integrative microbiome, metabolome and transcriptome analyses revealed distinct shifts in microbial composition and metabolite profiles, including elevated levels of citric acid, L-isoleucine (L-allo-Ile), and trans-cinnamic acid (tCA). Functional enrichment of differentially expressed metabolites and microbial taxa implicated pathways involved in oxidative defense, immune regulation, and PI3K-Akt-FoxO signaling. Functional enrichment analyses of differentially expressed metabolites (DEMs) and microbial taxa pointed to coordinated disruptions in redox homeostasis, cellular defense mechanisms, and host-microbe interactions. Collectively, our findings demonstrate that prolonged exposure to low temperatures and PS-NPs imposes considerable physiological burden on E. sinensis, manifested as metabolic dysregulation, oxidative damage, and impaired immune competence. This study provides a comprehensive molecular framework for understanding how E. sinensis responds to multifactorial environmental stressors, offering valuable insights for ecological risk assessment and resilience-oriented aquaculture practices.

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