您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Genome-wide methylation and transcriptome analysis in koi carp (Cyprinus carpio var. koi): Uncovering novel molecular mechanisms in skin color differentiation and pigmentation

文献类型： 外文期刊

作者： Shi, Xiulan 1 ; Chen, Xiaoyu 1 ; Zhu, Wenbin 2 ; Guo, Jun 3 ; Lin, Kai 3 ; Fu, Jianjun 2 ; Wang, Lanmei 2 ; Luo, Mingkun 2 ; Dong, Zaijie 1 ;

作者机构： 1.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214000, Jiangsu, Peoples R China

2.Chinese Acad Fishery Sci, Minist Agr & Rural Affairs, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resources, Wuxi 214000, Jiangsu, Peoples R China

3.Jiangsu Qihong Ecol Agr Dev Co Ltd, Suzhou 215416, Peoples R China

关键词： Koi carp; Skin color; DNA methylation; RNA-sequencing

期刊名称：AQUACULTURE （ 影响因子：3.9； 五年影响因子：4.4 ）

ISSN： 0044-8486

年卷期： 2026 年 610 卷

页码：

收录情况： SCI

摘要： Koi carp (Cyprinus carpio var. koi) are popular ornamental fish, and their complex mottling and patterning are ideal models for studying the regulatory mechanisms of pigmentation. However, there are few studies addressing the influence of epigenetics, especially DNA methylation on koi coloration and phenotype formation. In this study, we focused on three phenotypes of Kohaku offspring, namely the Rs group (all red-skinned), the Rw group (red-white-skinned) and the Ws group (all white-skinned), each of which underwent DNA methylation and transcriptome sequencing. A comprehensive analysis revealed that the genes in the differentially methylated regions and the differentially expressed genes (DEGs) were significantly enriched in pathways such as retinol metabolism and melanogenesis. The highest number of DEGs was observed in the Rs and Rw groups, while key genes involved in color differentiation, such as mitf, gch2 and bco1, were hypermethylated and regulated in the Rs group. Vivo experiments also showed that inhibition of methylation led to a significant increase in the expression of genes related to the retinol and pteridine pathway (e.g. pnp4a, gch2 and bco2) in the dorsal skin but not in the ventral skin. The results of in situ hybridization of carotenoid metabolism genes (bco1 and bco2) also suggest that DNA methylation is involved in the regulation of different color phenotypes and coloration in various parts of the body. These findings could deepen the understanding of the dynamic changes in DNA methylation that are crucial for the differentiation and variation of skin color in koi, thus revealing the potential influence of epigenetics on pigmentation.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台