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Toll and IMD Immune Pathways Are Important Antifungal Defense Components in a Pupal Parasitoid, Pteromalus puparum

文献类型： 外文期刊

作者： Yang, Lei 1 ; Yang, Lei 1 ; Wang, Xiaofu 1 ; Peng, Cheng 1 ; Chen, Xiaoyun 1 ; Wei, Wei 2 ; Xu, Xiaoli 1 ; Ye, Gongyin 2 ; Xu, Junfeng 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Traceabil Agr Genet Modified Organisms, Minist Agr & Rural Affairs, Hangzhou 310021, Peoples R China

2.Zhejiang Univ, Inst Insect Sci, State Key Lab Rice Biol & Breeding, Hangzhou 310058, Peoples R China

3.Zhejiang Univ, Inst Insect Sci, Key Lab Mol Biol Crop Pathogens & Insects, Minist Agr & Rural Affairs, Hangzhou 310058, Peoples R China

关键词： parasitoid; Toll pathway; IMD pathway; entomopathogenic fungi; scanning electron microscopy (SEM)

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.6； 五年影响因子：6.2 ）

ISSN： 1661-6596

年卷期： 2023 年 24 卷 18 期

页码：

收录情况： SCI

摘要： Insects employ multifaceted strategies to combat invading fungi, with immunity being a promising mechanism. Immune pathways function in signal transduction and amplification, ultimately leading to the activation of antimicrobial peptides (AMPs). Although several studies have shown that immune pathways are responsible for defending against fungi, the roles of parasitoid immune pathways involved in antifungal responses remain unknown. In this study, we evaluated the roles of the Toll and IMD pathways of a pupal parasitoid, Pteromalus puparum (Hymenoptera: Pteromalidae), in fighting against Beauveria bassiana (Hypocreales: Cordycipitaceae). Successful colonization of B. bassiana on P. puparum adults was confirmed by scanning electron microscopy (SEM). AMPs were induced upon B. bassiana infection. The knockdown of key genes, PpTollA and PpIMD, in Toll and IMD signaling pathways, respectively, significantly compromised insect defense against fungal infection. The knockdown of either PpTollA or PpIMD in P. puparum dramatically promoted the proliferation of B. bassiana, resulting in a decreased survival rate and downregulated expression levels of AMPs against B. bassiana compared to controls. These data indicated that PpTollA and PpIMD participate in Toll and IMD-mediated activation of antifungal responses, respectively. In summary, this study has greatly broadened our knowledge of the parasitoid antifungal immunity against fungi.

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