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Pharmacokinetics and residue elimination of metalaxyl enantiomers in snakehead (Channa argus)

文献类型： 外文期刊

作者： Zhou, Hao 1 ; Zhang, Meiyu 2 ; Shan, Qi 1 ; Huang, Heqing 1 ; Zhang, Meiling 1 ; Liu, Shugui 1 ; Lin, Jiawei 1 ; Ma, Lisha 1 ; Zheng, Guangming 1 ; Li, Lichun 1 ; Zhao, Cheng 1 ; Dai, Xiaoxin 1 ; Wei, Linting 1 ; Yin, Yi 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Guangzhou 510380, Peoples R China

2.Guangdong Polytech Sci & Trade, Coll Anim Sci & Technol, Guangzhou 510380, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Prevent & Control Aquat Invas Alien Specie, Guangzhou 510380, Peoples R China

4.Guangdong Prov Key Lab Aquat Anim Immunol & Sustai, Guangzhou 510380, Peoples R China

5.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China

关键词： Metalaxyl enantiomers; Stereoselectivity pharmacokinetics; Residues elimination; Liquid chromatography-tandem mass spectrometry; Snakehead(Channaargus)

期刊名称：AQUACULTURE （ 影响因子：4.5； 五年影响因子：4.6 ）

ISSN： 0044-8486

年卷期： 2023 年 567 卷

页码：

收录情况： SCI

摘要： Metalaxyl is widely used as a racemic mixture to control various plant and aquatic animal diseases caused by fungal infection. It has been proved that the two enantiomers of metalaxyl have significant differences in activity and toxicity, while little is known about the pharmacokinetics and residual elimination of the individual en-antiomers of metalaxyl in aquatic animals. In this study, a simple, sensitive and reliable chiral liquid chromatography-tandem mass spectrometry method was established for the determination of metalaxyl and its metabolite metalaxyl acid enantiomers, which was applied to study the stereoselective pharmacokinetics and residue elimination of individual enantiomers in snakehead (Channa argus). The snakehead was bath adminis-tered with the racemic metalaxyl and the highly active enantiomeric R-metalaxyl, respectively. The results showed that the elimination of metalaxyl in the plasma and tissues of snakehead was enantioselective. The concentration of metalaxyl in tissues was kidney > liver > muscle, and preferential degradation of the R-met-alaxyl enantiomer was observed in three tissues. However, no transformation between metalaxyl enantiomers was observed in snakehead plasma and tissues when R-metalaxyl enantiomer was administered. In addition, the distribution of metalaxyl acid enantiomers in tissues is closely related to the parent compound metalaxyl, and S-metalaxyl acid was only observed in the kidney and slowly eliminated. The highest concentrations of both metalaxyl and metalaxyl acid were observed in the kidney, suggesting that kidney is the major site of metalaxyl metabolism in snakehead. Given that the highly active R-metalaxyl has a shorter half-life and does not undergo transformation between enantiomers in snakehead, it may be a better choice to use R-metalaxyl instead of racemic metalaxyl in clinical practice. The results are helpful to understand the detailed fate of metalaxyl en-antiomers and should be considered in future aquaculture, environmental pollution risk and food safety evaluations.

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