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Characteristics and expression profiles of MHC class I molecules in Carassius auratus

文献类型： 外文期刊

作者： Xu, Chen 1 ; Xue, Mingyang 1 ; Jiang, Nan 1 ; Li, Yiqun 1 ; Meng, Yan 1 ; Liu, Wenzhi 1 ; Fan, Yuding 1 ; Zhou, Yong 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China

关键词： Targeted proteomics; Major histocompatibility complex class I; Carassius auratus; CyHV-2; Adaptive immunity

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2023 年 137 卷

页码：

收录情况： SCI

摘要： Major histocompatibility complex class I (MHC I) molecules play a vital role in adaptive immune systems in vertebrates by presenting antigens to effector T cells. Understanding the expression profiling of MHC I molecules in fish is essential for improving our knowledge of the relationship between microbial infection and adaptive immunity. In this study, we conducted a comprehensive analysis of MHC I gene characteristics in Carassius auratus, an important freshwater aquaculture fish in China that is susceptible to Cyprinid herpesvirus 2 (CyHV-2) infection. We identified approximately 20 MHC I genes discussed, including U, Z, and L lineage genes. However, only U and Z lineage proteins were identified in the kidney of Carassius auratus using high pH reversed-phase chromatography and mass spectrometry. The L lineage proteins were either not expressed or present at an extremely low level in the kidneys of Carassius auratus. We also used targeted proteomics to analyze changes in protein MHC I molecules abundance in healthy and CyHV-2-infected Carassius auratus. We observed that five MHC I molecules were upregulated, and Caau-UFA was downregulated in the diseased group. This study is the first to reveal the expression of MHC I molecules at a large scale in Cyprinids, which enhances our understanding of fish adaptive immune systems.

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