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β-Sitosterol Reduces the Content of Triglyceride and Cholesterol in a High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Zebrafish (Danio rerio) Model

文献类型： 外文期刊

作者： Zhang, Peng 1 ; Liu, Naicheng 1 ; Xue, Mingyang 1 ; Zhang, Mengjie 1 ; Xiao, Zidong 1 ; Xu, Chen 1 ; Fan, Yuding 1 ; Qiu, Junqiang 2 ; Zhang, Qinghua 2 ; Zhou, Yong 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China

2.Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China

3.Shanghai Ocean Univ, Natl Pathogen Collect Ctr Aquat Anim, Shanghai 201306, Peoples R China

关键词： beta-sitosterol; non-alcoholic fatty liver disease model; zebrafish; high-fat diet; blood fat untargeted lipidomics; lipid metabolism

期刊名称：ANIMALS （ 影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2024 年 14 卷 9 期

页码：

收录情况： SCI

摘要： beta-sitosterol is a natural product with significant lipid-lowering and cholesterol-lowering effects. However, the mechanism of its action on aquatic products is not fully understood. We selected zebrafish as the research object. Through the observation of lipids in zebrafish, we found that beta-sitosterol can reduce the accumulation of triglycerides and cholesterol in zebrafish, and reduce the related phenotypic changes caused by high-sugar and high-fat diet, thereby reducing lipid accumulation in zebrafish. This will provide a research basis for the development and use of beta-sitosterol. Objective: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with hyperlipidemia, which is closely related to high levels of sugar and fat. beta-sitosterol is a natural product with significant hypolipidemic and cholesterol-lowering effects. However, the underlying mechanism of its action on aquatic products is not completely understood. Methods: A high-fat diet (HFD)-induced NAFLD zebrafish model was successfully established, and the anti-hyperlipidemic effect and potential mechanism of beta-sitosterol were studied using oil red O staining, filipin staining, and lipid metabolomics. Results: beta-sitosterol significantly reduced the accumulation of triglyceride, glucose, and cholesterol in the zebrafish model. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that differential lipid molecules in beta-sitosterol mainly regulated the lipid metabolism and signal transduction function of the zebrafish model. beta-sitosterol mainly affected steroid biosynthesis and steroid hormone biosynthesis in the zebrafish model. Compared with the HFD group, the addition of 500 mg/100 g of beta-sitosterol significantly inhibited the expression of Ppar-gamma and Rxr-alpha in the zebrafish model by at least 50% and 25%, respectively. Conclusions: beta-sitosterol can reduce lipid accumulation in the zebrafish model of NAFLD by regulating lipid metabolism and signal transduction and inhibiting adipogenesis and lipid storage.

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