Inhibition of Glucosinolate Sulfatases to Combat Plutella xylostella: Development of Novel Phenylcarboxamide Derivatives for Plant-Integrated Pest Management
文献类型： 外文期刊
作者： Wang, Jiali 1 ; Wang, Manwen 1 ; Ravi, Anil 2 ; Zaraei, Seyed-Omar 2 ; Alkubaisi, Bilal O. 2 ; Wen, Yingjie 1 ; Zeng, Lingda 1 ; El-Gamal, Mohammed I. 2 ; Xu, Hanhong 1 ;
作者机构： 1.South China Agr Univ, Minist Educ, State Key Lab Green Pesticide, Key Lab Nat Pesticide & Chem Biol,Coll Plant Prote, Guangzhou 510642, Peoples R China
2.Univ Sharjah, Res Inst Med & Hlth Sci, Sharjah, U Arab Emirates
3.Shaoguan Univ, Guangdong Prov Key Lab Utilizat & Conservat Food &, Shaoguan 512005, Peoples R China
4.Guangdong Acad Agr Sci, Key Lab South Subtrop Fruit Biol & Genet Resource, Minist Agr & Rural Affairs, Guangzhou 510640, Peoples R China
5.Guangdong Acad Agr Sci, Inst Fruit Tree Res, Guangdong Prov Key Lab Sci & Technol Res Fruit Tre, Guangzhou 510640, Peoples R China
6.Univ Sharjah, Coll Pharm, Dept Med Chem, Sharjah, U Arab Emirates
7.Mansoura Univ, Fac Pharm, Dept Med Chem, Mansoura 35516, Egypt
关键词：
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）
ISSN： 0021-8561
年卷期： 2025 年 73 卷 19 期
页码：
收录情况： SCI
摘要： Glucosinolates in cruciferous plants are hydrolyzed by myrosinase to produce toxic isothiocyanates (ITCs). However, Plutella xylostella (P. xylostella), one of the top 10 global agricultural pests, utilizes glucosinolate sulfatases (GSSs) in its gut to convert glucosinolates into nontoxic desulfo-glucosinolates, thereby effectively avoiding the toxicity of ITCs. This study investigates the potential of inhibiting GSSs. Among 16 synthesized phenylcarboxamide derivatives, compound 1n exhibited strong inhibitory activity against GSS1 (59.72%) and GSS2 (88.47%), key enzymes involved in glucosinolate desulfation in P. xylostella, leading to toxic ITC accumulation and disrupted detoxification. This resulted in an approximately 30% reduction in larval weight, at a concentration of 100 mg/L, the mortality rate reached 96%. Importantly, in the absence of glucosinolates, these inhibitors showed no direct toxicity to the insect, indicating that their action relies on interaction with the plant's chemical defense system. These findings provide strong evidence supporting the development of GSSs inhibitions as more specific and selective insecticide, offering a promising alternative to conventional chemical pesticides.
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