文献类型： 外文期刊

作者： Liu, Junhan ¹ ; Li, Zhongzheng ¹ ; Sun, Mubai ¹ ; Zhou, Lianjie ¹ ; Wu, Xiaojun ¹ ; Lu, Yifei ¹ ; Shao, Yuting ⁷ ; Liu, Chang ¹ ; Huang, Ningge ¹ ; Hu, Bofan ¹ ; Wu, Zhongyuan ¹ ; You, Chunyu ¹ ; Li, Lizhu ⁸ ; Wang, Ming ³ ; Tao, Ling ¹⁰ ; Di, Zengfeng ¹¹ ; Sheng, Xing ¹² ; Mei, Yongfeng ¹ ; Song, Enming ¹ ;

作者机构： 1.Fudan Univ, Dept Mat Sci, Shanghai Frontiers Sci Res Base Intelligent Optoel, Shanghai 200438, Peoples R China

2.Fudan Univ, Inst Optoelect, Shanghai Frontiers Sci Res Base Intelligent Optoel, Shanghai 200438, Peoples R China

3.Fudan Univ, State Key Lab Integrated Chips & Syst, Shanghai 200438, Peoples R China

4.Fudan Univ, MOE Frontiers Ctr Brain Sci, Shanghai 200438, Peoples R China

5.Fudan Univ, Yiwu Res Inst, Yiwu 322000, Zhejiang, Peoples R China

6.Jilin Acad Agr Sci, Inst Agrofood Technol, Jilin Acad Agr Sci, Changchun 130033, Peoples R China

7.Tongji Univ, Tongji Hosp, Sch Med, Dept Ophthalmol, Shanghai 200065, Peoples R China

8.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Sichuan Prov Key Lab Human Dis Gene Study, Chengdu 611731, Peoples R China

9.Univ Elect Sci & Technol China, Ctr Med Genet, Sch Life Sci & Technol, Chengdu 611731, Peoples R China

10.Fudan Univ, Inst Nutr, Sch Publ Hlth, Dept Nutr & Food Hyg, Shanghai 200030, Peoples R China

11.Chinese Acad Sci, State Key Lab Funct Mat Informat, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China

12.Tsinghua Univ, Beijing Natl Res Ctr Informat Sci & Technol, Dept Elect Engn, Beijing 100084, Peoples R China

13.Tsinghua Univ, Inst Precis Med, Ctr Flexible Elect Technol, IDG McGovern Inst Brain Res, Beijing 100084, Peoples R China

关键词： temperature spatial mapping; wound inflammation; in situ therapy; closed- loop management; remote care

期刊名称：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA （ 影响因子：9.1； 五年影响因子：10.6 ）

ISSN： 0027-8424

年卷期： 2024 年 121 卷 49 期

页码：

收录情况： SCI

摘要： Continuous monitoring and closed- loop therapy of soft wound tissues is of particular interest in biomedical research and clinical practices. An important focus is on the development of implantable bioelectronics that can measure time- dependent temperature distribution related to localized inflammation over large areas ofwound and offer in situ treatment. Existing approaches such as thermometers/thermocouples provide limited spatial resolution, inapplicable to a wearable/implantable format. Here, we report a conformal, scalable device package that integrates a flexible amorphous silicon-based temperature sensor array and drug- loaded hydrogel for the healing process. This system can enable the spatial temperature mapping at submillimeter resolution and high sensitivity of 0.1 degrees C, for dynamically localizing the inflammation regions associated with temperature change, automatically followed with heat- triggered drug delivery from hydrogel triggered by wearable infrared light- emitting- diodes. We establish the operational principles experimentally and computationally and evaluate system functionalities with a wide range of targets including live animal models and human subjects. As an example of medical utility, this system can yield closed- loop monitoring/treatments by tracking of temperature distribution over wound areas of live rats, in designs that can be integrated with automated wireless control. These findings create broad utilities of these platforms for clinical diagnosis and advanced therapy for wound healthcare.