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Structures of a deltacoronavirus spike protein bound to porcine and human receptors

文献类型： 外文期刊

作者： Ji, Weiwei 1 ; Peng, Qi 2 ; Fang, Xueqiong 1 ; Li, Zehou 1 ; Li, Yaxin 1 ; Xu, Cunfa 5 ; Zhao, Shuqing 2 ; Li, Jizong 2 ; Chen, Rong 2 ; Mo, Guoxiang 1 ; Wei, Zhanyong 6 ; Xu, Ying 1 ; Li, Bin 2 ; Zhang, Shuijun 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Life Sci, Nanjing 210095, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr, Nanjing 210014, Peoples R China

3.State Key Lab Cultivat Base Minist Sci & Technol, Jiangsu Key Lab Food Qual & Safety, Nanjing 210014, Peoples R China

4.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225000, Jiangsu, Peoples R China

5.Jiangsu Acad Agr Sci, Cent Lab, Nanjing 210014, Peoples R China

6.Henan Agr Univ, Coll Vet Med, Zhengzhou 450046, Peoples R China

期刊名称：NATURE COMMUNICATIONS （ 2021影响因子：17.694； 五年影响因子：17.763 ）

ISSN：

年卷期： 2022 年 13 卷 1 期

页码：

收录情况： SCI

摘要： As a potential zoonotic pathogen, porcine deltacoronavirus (PDCoV) has been shown to cause febrile illness in humans. Here, Ji et al. report the structures of PDCoV spike protein bound to porcine and human aminopeptidase receptors, pointing to the likely underlying mechanism of PDCoV zoonotic transmission. Porcine deltacoronavirus (PDCoV) can experimentally infect a variety of animals. Human infection by PDCoV has also been reported. Consistently, PDCoV can use aminopeptidase N (APN) from different host species as receptors to enter cells. To understand this broad receptor usage and interspecies transmission of PDCoV, we determined the crystal structures of the receptor binding domain (RBD) of PDCoV spike protein bound to human APN (hAPN) and porcine APN (pAPN), respectively. The structures of the two complexes exhibit high similarity. PDCoV RBD binds to common regions on hAPN and pAPN, which are different from the sites engaged by two alphacoronaviruses: HCoV-229E and porcine respiratory coronavirus (PRCoV). Based on structure guided mutagenesis, we identified conserved residues on hAPN and pAPN that are essential for PDCoV binding and infection. We report the detailed mechanism for how a deltacoronavirus recognizes homologous receptors and provide insights into the cross-species transmission of PDCoV.

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