Comprehensive analysis of differentially expressed mRNA profiles in chicken jejunum and cecum following Eimeria maxima infection
文献类型： 外文期刊
作者： Jebessa, Endashaw 1 ; Bello, Semiu Folaniyi 1 ; Xu, Yibin 1 ; Cai, Bolin 1 ; Tuli, Merga Daba 5 ; Girma, Mekonnen 4 ; Bordbar, Farhad 1 ; Hanotte, Olivier 4 ; Nie, Qinghua 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Dept Anim Genet Breeding & Reprod, Guangzhou, Peoples R China
2.Minist Agr, Guangdong Prov Key Lab Agroanim Genom & Mol Breedi, Guangzhou, Peoples R China
3.Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou, Peoples R China
4.Int Livestock Res Inst ILRI, LiveGene Ctr Trop Livestock Genet & Hlth CTLGH, Addis Ababa, Ethiopia
5.Lanzhou Univ, Coll Pastoral Agr Sci & Technol, Lanzhou 730020, Peoples R China
6.Univ Nottingham, Sch Life Sci, Univ Pk, Nottingham, England
关键词： mRNA; chicken; differential expression; Eimeria maxima; jejunum and cecum
期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）
ISSN： 0032-5791
年卷期： 2024 年 103 卷 6 期
页码：
收录情况： SCI
摘要： Coccidiosis, a protozoan disease that substantially impacts poultry production, is characterized by an intracellular parasite. The study utilized 48 one -day -old Horro chickens, randomly divided into the infected ( I ) and control ( C ) groups. The challenge group of chickens were administered Eimeria maxima oocysts via oral gavage at 21 -days -old, and each chicken received 2 mL containing 7 10 pound 4 sporulated oocysts. The total RNAs of chicken jejunum and cecum tissues were isolated from three samples, each from I and C groups. Our study aimed to understand the host immune -parasite interactions and compare immune response mRNA pro files in chicken jejunum and cecum tissues at 4 and 7 days postinfection with Eimeria maxima . The results showed that 823 up- and 737 down -regulated differentially expressed mRNAs ( DEmRNAs ) in jejunum at 4 d infection and control (J4I vs. J4C), and 710 up- and 368 down -regulated DEmRNAs in jejunum at 7 days infection and control (J7I vs. J7C) were identi fied. In addition, DEmRNAs in cecum tissue, 1424 up- and 1930 down -regulated genes in cecum at 4 days infection and control (C4I vs. C4C), and 77 up- and 191 down -regulated genes in cecum at 7 days infection and control (C7I vs. C7C) were detected. The crucial DEmRNAs, including SLC7A5, IL1R2, GLDC, ITGB6, ADAMTS4, IL1RAP, TNFRSF11B, IMPG2, WNT9A , and FOXF1 , played pivotal roles in the immune response during Eimeria maxima infection of chicken jejunum. In addition, the potential detection of FSTL3, RBP7, CCL20, DPP4, PRKG2, TFPI2 , and CDKN1A in the cecum during the host immune response against Eimeria maxima infection is particularly noteworthy. Furthermore, our functional enrichment analysis revealed the primary involvement of DEmRNAs in small molecule metabolic process, immune response function, in flammatory response, and toll -like receptor 10 signaling pathway in the jejunum at 4 and 7 days postinfection. Similarly, in the cecum, DEmRNAs at 4 and 7 days postinfection were enriched in processes related to oxidative stress response and immune responses. Our findings provide new insights and contribute signi ficantly to the field of poultry production and parasitology.
- 相关文献
作者其他论文 更多>>
-
A large-scale comparison of the meat quality characteristics of different chicken breeds in South China
作者：Nie, Qinghua;Zhang, Xiquan;Luo, Wen;Nie, Qinghua;Zhang, Xiquan;Luo, Wen;Xiao, Liangchao;Qi, Lin;Fu, Rong;Nie, Qinghua;Zhang, Xiquan;Luo, Wen;Xiao, Liangchao;Qi, Lin;Fu, Rong;Nie, Qinghua;Zhang, Xiquan;Luo, Wen;Xiao, Liangchao;Qi, Lin;Fu, Rong;Nie, Qinghua;Zhang, Xiquan;Luo, Wen
关键词：South China; meat quality; broiler; cluster analysis; GWAS
-
Genetic characteristics and selection signatures between Southern Chinese local and commercial chickens
作者：Qi, Lin;Xiao, Liangchao;Fu, Rong;Nie, Qinghua;Zhang, Xiquan;Luo, Wen;Qi, Lin;Xiao, Liangchao;Fu, Rong;Nie, Qinghua;Zhang, Xiquan;Luo, Wen;Qi, Lin;Xiao, Liangchao;Fu, Rong;Nie, Qinghua;Zhang, Xiquan;Luo, Wen;Qi, Lin;Xiao, Liangchao;Fu, Rong;Nie, Qinghua;Zhang, Xiquan;Luo, Wen;Qi, Lin;Xiao, Liangchao;Fu, Rong;Nie, Qinghua;Zhang, Xiquan;Luo, Wen
关键词：population structure; genetic diversity; selection signature; South China native chicken; commercialization
-
Assessment of selective breeding effects and selection signatures in Qingyuan partridge chicken and its strains
作者：Kong, Shaofen;Cai, Bolin;Li, Xiaojing;Zhou, Zhen;Fang, Xiang;Yang, Xin;Cai, Danfeng;Nie, Qinghua;Kong, Shaofen;Cai, Bolin;Zhou, Zhen;Fang, Xiang;Yang, Xin;Cai, Danfeng;Nie, Qinghua;Kong, Shaofen;Cai, Bolin;Zhou, Zhen;Fang, Xiang;Yang, Xin;Cai, Danfeng;Nie, Qinghua;Kong, Shaofen;Cai, Bolin;Zhou, Zhen;Fang, Xiang;Yang, Xin;Cai, Danfeng;Nie, Qinghua;Luo, Xuehui;Guo, Suyin
关键词：Qingyuan partridge chicken; whole-genome resequencing; selective breeding; selection signatures; SNP
-
MeRIP sequencing reveals the regulation of N6-methyladenosine in muscle development between hypertrophic and leaner broilers
作者：Wang, Zhijun;Wang, Zhijun;Wang, Zhijun;Ju, Xing;Li, Kan;Cai, Danfeng;Zhou, Zhen;Nie, Qinghua;Wang, Zhijun;Ju, Xing;Li, Kan;Cai, Danfeng;Zhou, Zhen;Nie, Qinghua;Wang, Zhijun;Ju, Xing;Li, Kan;Cai, Danfeng;Zhou, Zhen;Nie, Qinghua
关键词：MeRIP; muscle development; broiler; N6-Methyladenosine; ALKBH5
-
The transmembrane protein TMEM182 promotes fat deposition and alters metabolomics and lipidomics
作者：Chen, Genghua;Lin, Zetong;Peng, Haoqi;Zhang, Shuai;Zhang, Zihao;Zhang, Xiquan;Nie, Qinghua;Luo, Wen;Chen, Genghua;Lin, Zetong;Peng, Haoqi;Zhang, Shuai;Zhang, Zihao;Zhang, Xiquan;Nie, Qinghua;Chen, Genghua;Lin, Zetong;Peng, Haoqi;Zhang, Shuai;Zhang, Zihao;Zhang, Xiquan;Nie, Qinghua
关键词：TMEM182; Fat formation; Metabolomics; Lipidomics
-
Using multiomics to explore the weight differences between genders in Muscovy ducks
作者：Tian, Jinghong;Tan, Liangtian;Wei, Shenghua;Yao, Zipei;Xu, Yibin;Nie, Qinghua;Tian, Jinghong;Tan, Liangtian;Wei, Shenghua;Yao, Zipei;Xu, Yibin;Nie, Qinghua;Tian, Jinghong;Tan, Liangtian;Wei, Shenghua;Yao, Zipei;Xu, Yibin;Nie, Qinghua;Tian, Jinghong;Tan, Liangtian;Wei, Shenghua;Yao, Zipei;Xu, Yibin;Nie, Qinghua;Zhu, Weijian;Ji, Congliang
关键词：Muscovy duck; sexual dimorphism; growth and development; RNA-seq; 16S rRNA sequencing technology
-
Live chicken body fat measurement technology based on bio-electrical impedance
作者：Liang, Jinping;Li, Zhenhui;Nie, Qinghua;Zhang, Dexiang;Zhang, Xiquan;Li, Hongmei;Zuo, Jiaming;Cheng, Shangshang;Li, Zhen;Zuo, Jiaming;Cheng, Shangshang;Li, Zhen;Liang, Jinping;Li, Zhenhui;Nie, Qinghua;Zhang, Dexiang;Zhang, Xiquan;Li, Hongmei;Liang, Jinping;Li, Zhenhui;Nie, Qinghua;Zhang, Dexiang;Zhang, Xiquan;Li, Hongmei;Liang, Jinping;Li, Zhenhui;Nie, Qinghua;Zhang, Dexiang;Zhang, Xiquan;Li, Hongmei;Deng, Yuelin
关键词：BIA; Electrical impedance; Fat content; Broilers
