Network analysis and in vivo experiments reveal the therapeutic mechanisms of total ginsenosides in a Drosophila model of ulcerative colitis
文献类型： 外文期刊
作者： He, Gongchen 1 ; Sun, Jian 2 ; Gu, Yuexin 2 ; Zheng, Yanjie 2 ; Wang, Liang 2 ; Sun, Yanyan 3 ;
作者机构： 1.Northwest A&F Univ, Coll Food Sci & Engn, Yangling, Shaanxi, Peoples R China
2.Jilin Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Changchun, Jilin, Peoples R China
3.Jilin Acad Agr Sci, Soybean Res Inst, Changchun, Jilin, Peoples R China
关键词：
total ginsenosides; ulcerative colitis; network analysis;
期刊名称：FRONTIERS IN PHARMACOLOGY （ 影响因子：4.8； 五年影响因子：5.2 ）
ISSN：
年卷期： 2025 年 16 卷
页码：
收录情况： SCI
摘要： Gut homeostasis is critical for human health, ulcerative colitis (UC) can disrupt gut homeostasis and cause disease. Panax ginseng C.A. Meyer is a widely used traditional herbal medicine known for its anti-inflammatory, antioxidant, and immunomodulatory effects. However, the protective mechanisms of total ginsenosides (TG) in treating UC remain unclear. In this study, we employed Drosophila melanogaster as a model organism to investigate the protective effects of TG on dextran sulfate sodium (DSS)-induced intestinal injury. Our data showed that TG significantly improved survival rates in female flies, restored intestinal length, maintained intestinal barrier integrity, and alleviated oxidative stress. Additionally, TG may protect against intestinal damage by activating the PI3K/Akt signaling pathway and inhibiting the JAK/STAT signaling pathway. These findings suggest that TG alleviates UC symptoms through multi-target regulation, highlighting its potential for developing novel therapeutic strategies for UC.
- 相关文献
作者其他论文 更多>>
-
The addition of vermiculite reduced antibiotic resistance genes during composting: Novel insights based on reducing host bacteria abundance and inhibiting plasmid-mediated conjugative transfer
作者：Sun, Yifan;Zhao, Zixuan;Gao, Zixuan;Hu, Tao;An, Lu;Gu, Jie;Wang, Xiaojuan;Gu, Jie;Wang, Xiaojuan;Sun, Jian;Guo, Honghong
关键词：Antibiotic resistance gene; Host bacteria; Mobile genetic elements; Conjugative transfer; Vermiculite
-
Genome-Wide Identification and Salt Stress-Responsive Expression Analysis of the GmPLATZ Gene Family in Soybean (Glycine max L.)
作者：Wang, Mingyu;Wu, Songquan;Shen, Mingzhe;Wang, Mingyu;Guan, Zheyun;Zhang, Jingyong;Lin, Chunjing;Sun, Yanyan;Zhang, Chunbao
关键词：soybean;
PLATZ gene family; genome-wide analysis; expression profile; salt stress -
The sustainable supply of lithium carbonate in China - Extracting brine-type lithium resource from salt lakes in the Qinghai-Xizang Plateau
作者：Yin, Zhenzhou;Zhao, Yimo;Wang, Gang;Guo, Bin;Ji, Puhui;Sun, Jian
关键词：New energy material; Extraction process; Life cycle assessment; Market environment; Policy support
-
Application of fly ash-based iron-doped lithium aluminum layered double hydroxide in brine-type lithium resources extraction: Adsorption mechanism analysis and life cycle assessment
作者：Yin, Zhenzhou;Zhao, Wenrui;Sun, Yutong;Wang, Gang;Ma, Tianhai;Ji, Puhui;Sun, Jian
关键词：Solid waste management; Sustainable production; Density functional theory; 2-dimensional correlation spectrum; Material flow analysis
-
Discovery, Optimization, and Biological Evaluation of Novel Pyrazol-5-yl-phenoxybenzamide Derivatives as Potent Succinate Dehydrogenase Inhibitors
作者：Xu, Dan;Lin, Guo-Tai;Huang, Jia-Chuan;Liu, Xili;Xu, Gong;Xu, Dan;Xu, Gong;Sun, Jian;Wang, Wei
关键词：pyrazole; diphenyl ether; antifungal activity; structure-activity relationships; molecular docking
-
Enhancing the carbon content of coal gangue for composting through sludge amendment: A feasibility study
作者：Luo, Chi;Li, Shaohua;Ren, Pengyu;Yan, Fan;Wang, Lu;Guo, Bin;Zhao, Yimo;Yang, Yue;Gao, Pengcheng;Ji, Puhui;Sun, Jian
关键词：High-carbon coal gangue; Sludge; Cocomposting; Maturity
-
Material flow analysis of heavy metals in large-scale cattle farms and ecological risk assessment of cattle manure application to fields
作者：Guo, Bin;Ren, Pengyu;Wang, Lu;Li, Shaohua;Luo, Chi;Zhao, Yimo;Ji, Puhui;Zhao, Hanghang;Sun, Jian
关键词：Large-scale farms; Forage; Cattle manure; Material flow analysis; Heavy metals; Ecological risks
