Integrated metabolomic and transcriptomic analysis revealed the flavonoid biosynthesis and regulation in Areca catechu
文献类型： 外文期刊
作者： Yu, Dong 1 ; Zhang, Kelan 1 ; Wu, Jiao 2 ; Li, Xinyu 1 ; Zhou, Guangzhen 1 ; Wan, Yinglang 1 ;
作者机构： 1.Hainan Univ, Coll Trop Crops, Hainan Key Lab Sustainable Utilizat Trop Bioresour, Haikou 570228, Hainan, Peoples R China
2.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Haikou 571737, Hainan, Peoples R China
关键词： Areca catechu L; biosynthesis; flavonoid; metabolomic; transcriptomic
期刊名称：PHYTOCHEMICAL ANALYSIS （ 影响因子：3.3； 五年影响因子：3.2 ）
ISSN： 0958-0344
年卷期： 2023 年 34 卷 3 期
页码：
收录情况： SCI
摘要： IntroductionFlavonoids are active substances in many herbal medicines, and Areca catechu fruit (AF), an important component in traditional Chinese medicine (TCM), is rich in flavonoids. Different parts of AF, Pericarpium Arecae (PA) and Semen Arecae (SA), have different medicinal effects in prescription of TCM. ObjectiveTo understand flavonoid biosynthesis and regulation in AF. MethodologyThe metabolomic based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) and the transcriptome based on high-throughput sequencing technology were combined to comprehensively analyse PA and SA. ResultsFrom the metabolite dataset, we found that 148 flavonoids showed significant differences between PA and SA. From the transcriptomic dataset, we identified 30 genes related to the flavonoid biosynthesis pathway which were differentially expressed genes in PA and SA. The genes encoding the key enzymes in the flavonoid biosynthesis pathway, chalcone synthase and chalcone isomerase (AcCHS4/6/7 and AcCHI1/2/3), were significantly higher expressed in SA than in PA, reflecting the high flavonoid concentration in SA. ConclusionsTaken together, our research acquired the key genes, including AcCHS4/6/7 and AcCHI1/2/3, which regulated the accumulation of flavonol in AF. This new evidence may reveal different medicinal effects of PA and SA. This study lays a foundation for investigating the biosynthesis and regulation of flavonoid biosynthesis in areca and provides the reference for the production and consumption of betel nut.
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