Hypothetical bromodomain-containing protein 5 is required for the growth of Toxoplasma gondii
文献类型： 外文期刊
作者： Zhang, Ying 1 ; Cheng, Long 2 ; Qiu, Hongyu 1 ; Sun, Tiancong 2 ; Deng, Ruipeng 1 ; Gong, Haiyan 2 ; Mi, Rongsheng 2 ; Huang, Yan 2 ; Wang, Chunren 1 ; Chen, Zhaoguo 2 ;
作者机构： 1.Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Daqing 163319, Heilongjiang, Peoples R China
2.Chinese Acad Agr Sci, Minist Agr, Shanghai Vet Res Inst, Key Lab Anim Parasitol,Lab Qual & Safe Risk Asses, Shanghai 200241, Peoples R China
3.Heilongjiang Acad Agr Sci, Branch Anim Husb & Vet, Qiqihar 161000, Heilongjiang, Peoples R China
关键词： Toxoplasma gondii; Bromodomain-containing protein 5; Localization; Proliferation; Conditional ablation
期刊名称：VETERINARY PARASITOLOGY （ 影响因子：2.821； 五年影响因子：2.862 ）
ISSN： 0304-4017
年卷期： 2022 年 309 卷
页码：
收录情况： SCI
摘要： Bromodomain (BRD) is a highly conserved structural module domain, found in various proteins, including chromatin-related proteins, nucleus acetyltransferases, and transcription-associated proteins. Toxoplasma gondii, a zoonotic protozoan, encodes at least 12 predicted BRD-containing proteins (BDPs). Here, we investigated the subcellular location and regulatory role of a hypothetical protein BDP that we named TgBDP5. The BRD of TgBDP5 did not contain the conserved Asn and Tyr residues required for acetyl-lysine recognition. TgBDP5 localized in the nucleus of the parasite and remained unchanged during parasite replication. Conditional ablation of TgBDP5 through an auxin-inducible degron-based knockdown strategy caused a growth defect in parasite replication. Depletion of TgBDP5 led to changes in the expression level of 179 genes, suggesting it as an important target for drugs acting against T. gondii.
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