Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?
文献类型： 外文期刊
作者： He, Zuyong 1 ; Zhao, Yiqiang 1 ; Mei, Gui 2 ; Li, Ning 3 ; Chen, Yaosheng 1 ;
作者机构： 1.Sun Yat Sen Univ, State Key Lab Biocontrol, Sch Life Sci, Guangzhou 510006, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou 510640, Peoples R China
3.China Agr Univ, State Key Lab Agrobiotechnol, Beijing 100193, Peoples R China
关键词： transgene: expression;therapeutic recombinant protein: expression;GenBank sequence data;protein tertiary structure;tissue specific codon usage pattern
期刊名称：TRANSGENIC RESEARCH （ 影响因子：2.788； 五年影响因子：2.377 ）
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收录情况： SCI
摘要： Animal mammary glands have been successfully employed to produce therapeutic recombinant human proteins. However, considerable variation in animal mammary transgene expression efficiency has been reported. We now consider whether aspects of codon usage and/or protein tertiary structure underlie this variation in mammary transgene expression.
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