文献类型： 外文期刊

作者： Zeng, Haonan ¹ ; Zhang, Wenjing ¹ ; Lin, Qing ¹ ; Gao, Yahui ¹ ; Teng, Jinyan ¹ ; Xu, Zhiting ¹ ; Cai, Xiaodian ¹ ; Zhong, Zhanming ¹ ; Wu, Jun ¹ ; Liu, Yuqiang ¹ ; Diao, Shuqi ¹ ; Wei, Chen ¹ ; Gong, Wentao ¹ ; Pan, Xiangchun ¹ ; Li, Zedong ¹ ; Huang, Xiaoyu ¹ ; Chen, Xifan ¹ ; Du, Jinshi ¹ ; PigGTEx Consortium, Fuping ¹ ; Zhao, Fuping ² ; Zhao, Yunxiang ³ ; Ballester, Maria ⁴ ; Crespo-Piazuelo, Daniel ⁴ ; Amills, Marcel ⁵ ; Clop, Alex ⁵ ; Karlskov-Mortensen, Peter ⁸ ; Fredholm, Merete ⁸ ; Li, Pinghua ⁹ ; Huang, Ruihua ⁹ ; Tang, Guoqing ¹¹ ; Li, Mingzhou ¹¹ ; Liu, Xiaohong ¹¹ ; Chen, Yaosheng ¹¹ ; Zhang, Qin ¹² ; Li, Jiaqi ¹ ; Yuan, Xiaolong ¹ ; Ding, Xiangdong ¹³ ; Fang, Lingzhao ¹⁴ ; Zhang, Zhe ¹ ;

作者机构： 1.South China Agr Univ, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Natl Engn Res Ctr Breeding Swine Ind, Coll Anim Sci,State Key Lab Swine & Poultry Breedi, Guangzhou 510642, Peoples R China

2.Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100193, Peoples R China

3.Guangxi Univ, Coll Anim Sci & Technol, Nanning 530004, Peoples R China

4.Inst Recerca & Tecnol Agroalimentaries, Anim Breeding & Genet Programme, Torre Marimon, Caldes De Montb, Spain

5.UB, Ctr Res Agr Genom CRAG, Dept Anim Genet, CSIC IRTA UAB, Campus Univ Autonoma Barcelona, Barcelona 08193, Spain

6.Univ Autonoma Barcelona, Dept Ciencia Anim & Dels Aliments, Bellaterra 08193, Spain

7.CSIC, Barcelona, Catalonia, Spain

8.Univ Copenhagen, Dept Vet & Anim Sci, Anim Genet Bioinformat & Breeding, DK-1870 Frederiksberg, Denmark

9.Nanjing Agr Univ, Inst Swine Sci, Nanjing 210095, Peoples R China

10.Minist Agr & Rural Areas, Key Lab Nanjing Evaluat & Utilizat Livestock & Pou, Nanjing 210095, Peoples R China

11.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou, Peoples R China

12.Shandong Agr Univ, Coll Anim Sci & Technol, Tai An 271018, Peoples R China

13.China Agr Univ, Coll Anim Sci & Technol, Beijing 100193, Peoples R China

14.Aarhus Univ, Ctr Quantitat Genet & Genom QGG, Aarhus, Denmark

期刊名称：NUCLEIC ACIDS RESEARCH （ 影响因子：14.9； 五年影响因子：16.4 ）

ISSN： 0305-1048

年卷期： 2023 年

页码：

收录情况： SCI

摘要： To fully unlock the potential of pigs as both agricultural species for animal-based protein food and biomedical models for human biology and disease, a comprehensive understanding of molecular and cellular mechanisms underlying various complex phenotypes in pigs and how the findings can be translated to other species, especially humans, are urgently needed. Here, within the Farm animal Genotype-Tissue Expression (FarmGTEx) project, we build the PigBiobank (http:////pigbiobank.farmgtex.org) to systematically investigate the relationships among genomic variants, regulatory elements, genes, molecular networks, tissues and complex traits in pigs. This first version of the PigBiobank curates 71 885 pigs with both genotypes and phenotypes from over 100 pig breeds worldwide, covering 264 distinct complex traits. The PigBiobank has the following functions: (i) imputed sequence-based genotype-phenotype associations via a standardized and uniform pipeline, (ii) molecular and cellular mechanisms underlying trait-associations via integrating multi-omics data, (iii) cross-species gene mapping of complex traits via transcriptome-wide association studies, and (iv) high-quality results display and visualization. The PigBiobank will be updated timely with the development of the FarmGTEx-PigGTEx project, serving as an open-access and easy-to-use resource for genetically and biologically dissecting complex traits in pigs and translating the findings to other species. Graphical Abstract