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Highly-hydrophobic nanofiber mat for efficient colonic delivery of lactoferrin: Preparation, characterization and release mechanism

文献类型： 外文期刊

作者： Wei, Yun-Shan 1 ; Feng, Kun 2 ; Li, Shu-Fang 1 ; Hu, Teng-Gen 2 ; Zong, Min-Hua 1 ; Wu, Hong 1 ;

作者机构： 1.South China Univ Technol, Sch Food Sci & Engn, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Guangzhou 510640, Peoples R China

2.Zhengzhou Univ Light Ind, Coll Food & Bioengn, Henan Key Lab Cold Chain Food Qual & Safety Contro, Zhengzhou 450001, Peoples R China

3.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Key Lab Funct Foods, Guangdong Key Lab Agr Prod Proc,Minist Agr, Guangzhou, Peoples R China

关键词： Highly-hydrophobic; Lactoferrin; Eudragit S100; Water-in-oil emulsion; Coaxial electrospinning; Colonic delivery

期刊名称：INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES （ 影响因子：7.104； 五年影响因子：7.391 ）

ISSN： 1466-8564

年卷期： 2022 年 78 卷

页码：

收录情况： SCI

摘要： Lactoferrin (Lf) is a bioactive protein with varied biological effects. To improve its anti-digestive stability in oral administration, a novel nanocarrier with high hydrophobicity for colonic delivery of Lf was creatively developed by modified coaxial electrospinning. First, a suitable biocompatible solvent, acetic acid, was screened as the mono-solvent for ES100 electrospinning, creating highly-hydrophobic ES100 nanofiber mat (contact angle = 133.8o). Then, Lf-loaded W/O emulsion was prepared as the core fluid to ensure the successful coaxial electrospinning and generate Lf encapsulated core/shell nanofiber mat (ES@Lf). Lf was demonstrated maintaining structural integrity and anti-colon cancer activity during encapsulation and oral delivery. In vitro assay indicated 92.3% Lf was sustainably released in colon, and its release followed a complex mechanism in which the erosion was dominant. Instead of pH-dependent erosion, the synergistic action through gut microbiota adhesion and their metabolites, especially short-chain fatty acids, was illustrated for disintegration of ES@Lf nanofiber for the first time.

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