Fabrication and characterization of shellac nanofibers with colon-targeted delivery of quercetin and its anticancer activity
文献类型： 外文期刊
作者： Li, Shu-Fang 1 ; Hu, Teng-Gen 2 ; Jin, Yuan-Bao 3 ; Wu, Hong 1 ;
作者机构： 1.South China Univ Technol, Sch Food Sci & Engn, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Guangzhou 510641, Peoples R China
2.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Key Lab Funct Foods, Minist Agr,Guangdong Key Lab Agr Prod Proc, Guangzhou 510610, Guangdong, Peoples R China
3.Jian Coll, Modern Agr & Forestry Engn Coll, Jian 343000, Peoples R China
关键词： Shellac nanofibers; Electrospinning; Colon-targeted delivery; Quercetin; Anticancer activity
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）
ISSN： 0141-8130
年卷期： 2024 年 265 卷
页码：
收录情况： SCI
摘要： In this study, the feasibility of shellac nanofibers as carrier system for colonic delivery of quercetin was evaluated. Firstly, the nanofibers without and with different amounts (2.5 %, 5.0 %, and 7.5 %) of quercetin were fabricated using pure shellac as a carrier by electrospinning. The morphology of nanofibers was bead-shape confirmed by SEM. FTIR, XRD, and DSC analysis showed that quercetin was encapsulated into shellac nanofibers, forming an amorphous complex. The molecular docking simulation indicated quercetin bound well to shellac through hydrogen bonding and van der Waals forces. These nanofibers had higher thermal stability than pure quercetin, and their surface wettability exhibited a pH-responsive behavior. The loading capacity of quercetin varied from 2.25 % to 6.84 % with the increased amount of quercetin, and it affected the stability of nanofibers in food simulants by measuring the release profiles of quercetin. The shellac nanofibers had high gastrointestinal stability, with a minimum quercetin release of 16.87 % in simulated digestive fluids, while the remaining quercetin was delivered to the colon and was released gradually. Moreover, the nanofibers exerted enhanced anticancer activity against HCT-116 cells by arresting cell cycle in G0/G1 phase and inducing cell apoptosis. Overall, shellac nanofibers are promising materials for colon-targeted delivery of active compounds.
- 相关文献
作者其他论文 更多>>
-
Fabrication of multifunctional ethyl cellulose/gelatin-based composite nanofilm for the pork preservation and freshness monitoring
作者：Wu, Jia-hui;Liao, Jia-hui;Zong, Min-hua;Wu, Hong;Wen, Peng;Hu, Teng-gen
关键词：Electrospinning; Intelligent nanofilm; Multifunctional properties; Pork freshness and preservation
-
Probiotic-fermented edible herbs as functional foods: A review of current status, challenges, and strategies
作者：Cui, Rui;Zhang, Cong;Pan, Zhen-Hui;Wu, Hong;Hu, Teng-Gen
关键词：biotransformation; fermentation; health benefits; medicine and food homology; probiotic
-
Trans-cinnamaldehyde inhibits Escherichia coli growth by regulating lipopolysaccharide accumulation
作者：Xing, Huanling;Liu, Xiaomin;Lin, Jianhao;Huang, Junyi;Li, Xinghai;Li, Yanqun;Guo, Shining;Wu, Hong;Wu, Hong;Sun, Mingfei;Zhou, Fang
关键词：Trans-cinnamaldehyde; Resistant Escherichia coli; Susceptible Escherichia coli; Cell wall; LPS
-
Development of quercetin-loaded electrospun nanofibers through shellac coating on gelatin: Characterization, colon-targeted delivery, and anticancer activity
作者：Li, Shu-Fang;Wu, Hong;Hu, Teng-Gen
关键词：Shellac coating; Gelatin; Coaxial electrospinning; Colon-targeted delivery system; Anticancer activity
-
In vivo antioxidant activity of Cinnamomum cassia leaf residues and their effect on gut microbiota of d-galactose-induced aging model mice
作者：Chen, Lingqi;Wang, Hong;Wen, Peng;Hu, Tenggen;Wu, Ruiqing;Wu, Hong
关键词：Cinnamomum cassia leaf residues; antioxidant; anti-inflammatory; anti-aging; gut microbiota
-
Phenotypic screening of novel probiotics with potential anti-neuroinflammation activity based on cell and zebrafish models
作者：He, Bao-Lin;Wu, Hong;Hu, Teng-Gen
关键词：Probiotic; Anti-Neuroinflammation; Screen; Cell-zebrafish model
-
Interaction mechanism of carotenoids and polyphenols in mango peels
作者：Hu, Yu-Qing;Hu, Teng-Gen;Xu, Yu-Juan;Wu, Ji-Jun;Yu, Yuan-Shan;Hu, Yu-Qing;Song, Xian-Liang;Xu, Yu-Juan;Hu, Teng-Gen;Yu, Yuan-Shan
关键词：Carotenoid; Electrostatic adsorption; Hydrogen bonding; Interaction; Mango peel; Polyphenol; van der Waals forces
