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Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems

文献类型： 外文期刊

作者： Walczynska, Katarzyna S. 1 ; Zhu, Ling 2 ; Liang, Yujun 1 ;

作者机构： 1.Ocean Univ China, Inst Evolut & Marine Biodivers, Coll Marine Life Sci, Qingdao 266003, Peoples R China

2.Minist Agr & Rural Affairs, Yellow Sea Fisheries Res Inst, Chinese Acad Fishery Sci, Shandong Prov Key Lab Fishery Resources & Ecol Env, Qingdao 266071, Peoples R China

3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China

关键词： regeneration; Wnt/[3-catenin; signalling pathway; model organisms

期刊名称：INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY （ 影响因子：0.7； 五年影响因子：1.5 ）

ISSN： 0214-6282

年卷期： 2023 年 67 卷 3 期

页码：

收录情况： SCI

摘要： Regeneration enables the regrowth and restoration of missing body parts. It is a common phenomenon among animals. However, only some species exhibit remarkable regeneration capabilities and can regenerate organs such as limbs, lenses or hearts. Regeneration has been widely studied, thereby giving rise to new fields, such as regenerative medicine. Furthermore, regeneration has the potential to be applied to the human body. However, the molecular mechanisms governing this process should be elucidated first. Recent advancements in research methods have led to the identification of numerous signaling pathways involved in regeneration. One of them, the Wnt transduction pathway, is an ancient and evolutionarily conserved pathway that plays an important role in both embryonic development and regeneration. The Wnt pathway plays an important role during the regeneration process, as it is implicated in cell fate determination, cell migration, cell polarity and adult cell homeostasis. To date, two major Wnt pathways have been identified: the canonical (13-catenin dependent) pathway and the non-canonical pathway. The latter pathway can be further divided into planar cell polarity, the Wnt/Ca2+ pathway and the JNK pathway. In this review, we summarize the current state of knowledge regarding the Wnt signaling pathway and its role in regeneration, with a particular emphasis on key model species.

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