Protective Effect and Mechanism of Plant-Based Monoterpenoids in Non-alcoholic Fatty Liver Diseases
文献类型： 外文期刊
作者： Zhang, Wenji 1 ; Lin, Hui 2 ; Cheng, Wenli 3 ; Huang, Zhenrui 1 ; Zhang, Wenjuan 3 ;
作者机构： 1.Guangdong Acad Agr Sci, Guangdong Prov Engn & Technol Res Ctr Tobacco Bre, Crops Res Inst, Key Lab Crop Genet Improvement Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China
2.Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Radiat Oncol, Guangzhou 510080, Guangdong, Peoples R China
3.Jinan Univ, Sch Med, Dept Publ Hlth & Prevent Med, Guangzhou 510632, Peoples R China
关键词： non-alcoholic fatty liver diseases; NAFLD; monoterpenoids; iridoid glycosides
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.895； 五年影响因子：6.048 ）
ISSN： 0021-8561
年卷期： 2022 年 70 卷 16 期
页码：
收录情况： SCI
摘要： The protective effect of plant active ingredients against non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prominent, and the terpenoids have always been the main active compounds in Chinese herbal medicine exerting hepatoprotective effects. However, the related pharmacological effects, especially for monoterpenoids or iridoid glycosides, which have obvious effects on improvement of NAFLD, have not been systematically analyzed. The objective of this review is to systematically examine the molecular mechanisms of monoterpenoids in NAFLD. The signaling pathways of peroxisome proliferator-activated receptor, insulin, nuclear factor.B, toll-like receptor, adipocytokine, RAC-a serine/threonine protein kinase, mammalian target of rapamycin, 5'-AMP-activated protein kinase, and autophagy have been proven to mediate this protective effect. We further compared the experimental data from animal models, including the dosage of these monoterpenoids in detail, and demonstrated that they are effective and safe candidate drugs for NAFLD. This review provides a reference for the development of NAFLD drugs as well as a research guideline for the potential uses of plant monoterpenoids.
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