Chinese Tea Alleviates CCl4-Induced Liver Injury through the NF-kappa BorNrf2Signaling Pathway in C57BL-6J Mice
文献类型： 外文期刊
作者： Wu, Zhaoyu 1 ; Sun, Lingli 1 ; Chen, Ruohong 1 ; Wen, Shuai 1 ; Li, Qiuhua 1 ; Lai, Xingfei 1 ; Zhang, Zhenbiao 1 ; Cao, Fanrong 2 ; Sun, Shili 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Key Lab Tea Resources Innovat & Utiliza, Guangzhou 510640, Peoples R China
2.South China Agr Univ, Dept Tea Sci, Coll Hort, Guangzhou 510641, Peoples R China
关键词： tea; liver injury; anti-inflammation; NF-kappa B pathway; Nrf2 pathway
期刊名称：NUTRIENTS （ 影响因子：6.706； 五年影响因子：7.185 ）
ISSN：
年卷期： 2022 年 14 卷 5 期
页码：
收录情况： SCI
摘要： Liver injury is a life-threatening condition that is usually caused by excessive alcohol consumption, improperdiet, and stressful lifestyle and can even progress to liver cancer. Tea is a popular beverage with proven health benefits and is known to exert a protective effect on the liver, intestines, and stomach. In this study, we analyzed the therapeutic effects of six kinds of tea on carbon tetrachloride (CCl4)-induced liver injury in a mouse model. The mice were injected with 10 mL/kg 5% CCl4 to induce liver injury and then given oral gavage of green tea, yellow tea, oolong tea, white tea, black tea, and dark tea, respectively. The serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured, and the expression levels of inflammation and oxidative stress-related proteins in the liver tissues were quantified. All six kinds of tea partly reduced the liver index, restored the size of the enlarged liver in the CCl4 model, and decreased the serum levels of ALT and AST. Furthermore, the highly fermented dark tea significantly reduced the expression levels of NF-kappa B and the downstream inflammatory factors, whereas the unfermented green tea inhibited oxidative stress by activating the antioxidant Nrf2 pathway. Taken together, tea can protect against liver inflammation, and unfermented tea can improve antioxidant levels. Further studies are needed on the bioactive components of tea to develop drugs against liver injury.
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