The mechanisms of hydroxy-a-sanshool from Zanthoxyum bungeanum maxim activates AMPK-HIF1-PKM2 pathway to fix the obesity
文献类型： 外文期刊
作者： Ren, Tingyuan 1 ; Zhu, Yuping 2 ; Xu, Fangyan 1 ; Lu, Mintao 6 ; Qin, Likang 1 ; Zhao, Degang 3 ;
作者机构： 1.Guizhou Univ, Coll Brewing & Food Engn, Guiyang 55025, Peoples R China
2.Guizhou Med Univ, Sch Basic Med, Guiyang 550025, Peoples R China
3.Guizhou Univ, Inst Agrobioengn, Guiyang 550025, Guizhou, Peoples R China
4.Guizhou Univ, Coll Life Sci, Key Lab Plant Resources Conservat & Germplasm Inno, Minist Educ, Guiyang 550025, Guizhou, Peoples R China
5.Guizhou Acad Agr Sci, Inst Guizhou Distinct Plant Resources Conservat, Guiyang 550006, Guizhou, Peoples R China
6.Guizhou Modern Seed Ind Grp Co Ltd, Guiyang 550006, Guizhou, Peoples R China
7.Guizhou Univ, Coll Brewing & Food Engn, Guiyang 550025, Peoples R China
关键词： Zanthoxylum bungeanum; Hydroxy-& alpha;-sanshool; High-fat diet; Lipid metabolism; Oxidative stress
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）
ISSN： 1756-4646
年卷期： 2023 年 107 卷
页码：
收录情况： SCI
摘要： To explore effects of hydroxy-a-sanshool (HAS) on metabolism disorder and oxidative stress induced by high-fat diet. The 50 SD male rats were divided into normal group (NC), high-fat group (MC) and HAS groups. Some key indexes, metabolites and signaling molecules were determined. The results showed that compared with MC, HAS significantly reduced body weight, contents of TC, TG, LDL-C, HIF-1, ATP, LDH, CPT and CS in liver; increased activity of SOD and CAT in liver and serum. The identified 7 differential metabolites by UPLC/HRMS were enriched to 18 metabolic pathways including ascorbate metabolism, glutathione metabolism, HIF-1 and glucagon pathway. Furtherly, Western blot showed that increased protein abundance of p-AMPK, p-ACC, Nrf2 and HO-1; reduced that of HIF-1a, p-PKM2 (Tyr105) and CPT1A in HAS groups. It was indicated that HAS activates AMPK-HIF1-PKM2 pathway and Nrf2/HO1 pathway to reduce oxidative damage and improve lipid and energy metabolism disorder caused by high-fat diet.
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