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Ethoxyquin attenuates enteric oxidative stress and inflammation by promoting cytokine expressions and symbiotic microbiota in heat-stressed broilers

文献类型： 外文期刊

作者： Elokil, Abdelmotaleb 1 ; Li, Shijun 1 ; Chen, Wei 2 ; Farid, Omar 4 ; Abouelezz, Khaled 1 ; Zohair, Khairy 1 ; Nassar, Farid 1 ; El-komy, Esteftah 8 ; Farag, Soha 7 ; Elattrouny, Mahmoud 3 ;

作者机构： 1.Huazhong Agr Univ, Coll Anim Sci & Vet Med, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Hubei, Peoples R China

2.Minist Agr & Rural Affairs, Inst Anim Sci, State Key Lab Swine & Poultry Breeding Ind, Guangdong Acad Agr Sci,Key Lab Anim Nutr & Feed Sc, Guangzhou 510640, Peoples R China

3.Benha Univ, Fac Agr, Dept Anim Prod, Moshtohor 13736, Egypt

4.Natl Org Drug Control & Res, Dept Physiol, Giza 12553, Egypt

5.Assiut Univ, Fac Agr, Dept Poultry Prod, Assiut 71526, Egypt

6.Biotechnol Res Inst, Natl Res Ctr, Cell Biol Dept, Giza 12622, Egypt

7.Cairo Univ, Fac Agr, Dept Anim Prod, Giza 12613, Egypt

8.Agr & Biol Res Inst, Natl Res Ctr, Anim Prod Dept, Giza 12622, Egypt

9.Tanta Univ, Fac Agr, Dept Anim Prod, Tanta, Egypt

关键词： ethoxyquin; heat-stressed broiler; enteric oxidative stress; antioxidant capacity; symbiotic gut

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 6 期

页码：

收录情况： SCI

摘要： Intestinal oxidative stress in broilers is produced by chronic heat stress (HS) and has a negative impact on poultry performance as it induces intestinal in flammation and promotes the invasion of gram-negative bacteria, such as bacterial lipopolysaccharide (LPS). Therefore, dietary inclusion of the antioxidant compound, ethoxyquin (EQ), could improve enteric antioxidant capacity, immune responses, and the epithelial barrier, and maintain the symbiotic gut microbiota community. To investigate the effects of EQ supplementation on alleviating enteric oxidative stress in heatstressed broilers, 200 one-day-old male Ross 308 broilers were randomly assigned to 4 groups (n = 50 chicks/group; n = 10 chicks/replicate) and fed a basal diet supplemented with 0 (CT), 50 (EQ-50), 100 (EQ-100), and 200 (EQ-200) mg EQ/ kg(-1) for 5 wk. The chicks were raised in floor pens inside the broiler farm at a temperature and humidity index (THI) of 29 from d 21 to d 35. Growth performance traits, relative organ index, hepatic antioxidant enzymes, serum immunity, total adenylate, and cytokine activities were improved in the EQ-50 group (linear or quadratic P < 0.05), promoting the relative mRNA expression of cytokine gene-related antiin flammatory and growth factors. A distinct microbial community colonised the gut microbiota in the EQ-50 group, with a high relative abundance of Lactobacillus, Ligilactobacillus, Limosilactobacillus, Pediococcus, Blautia , and Faecalibacterium compared to the other groups. Dietary supplementation with 50 mg EQ/ kg(-1) for 5 wk attenuates enteric oxidative stress and intestinal in flammation by enhancing serum immune and cytokine content (IgG, IL-6, and TGF-beta,) and symbiotic microbiota in heat-stressed broilers. EQ promotes the expression of Hsp70, SOD2, GPx 4, IL-6, and IGF-1 cytokine gene-related anti-in flammatory and growth factors in heat-stressed hepatic broilers. Collectively, EQ-50 could be a suitable feed supplement for attenuating enteric oxidative stress and intestinal in flammation, thereby promoting the productivity of heat-stressed broilers.

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