文献类型： 外文期刊

作者： Zhou, Luli ¹ ; Abouelezz, Khaled ¹ ; Momenah, Maha Abdullah ³ ; Bajaber, Majed A. ⁴ ; Baazaoui, Narjes ⁵ ; Taha, Taha F. ⁶ ; Awad, Ahmed E. ⁶ ; Alamoudi, Soha A. ⁷ ; Beyari, Eman A. ⁸ ; Alanazi, Yasmene F. ⁹ ; Allohibi, Aminah ⁷ ; Saad, Ahmed M. ⁶ ;

作者机构： 1.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Haikou 571101, Peoples R China

2.Assiut Univ, Fac Agr, Dept Poultry Prod, Assiut 71526, Egypt

3.Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Biol, Riyadh 11671, Saudi Arabia

4.King Khalid Univ, Fac Sci, Chem Dept, Abha 61413, Saudi Arabia

5.King Khalid Univ, Coll Sci & Arts Muhayil Assir, Biol Dept, Abha 61421, Saudi Arabia

6.Zagazig Univ, Fac Agr, Biochem Dept, Zagazig 44511, Egypt

7.King Abdulaziz Univ, Coll Sci & Arts, Biol Sci Dept, Rabigh 21911, Saudi Arabia

8.King Abdulaziz Univ, Fac Sci, Dept Biol Sci, Microbiol, Jeddah 21589, Saudi Arabia

9.Univ Tabuk, Fac Sci, Dept Biochem, Tabuk 71491, Saudi Arabia

关键词： antibiotics alternatives; cecal microbiota; organic poultry; Paenibacillus polymyxa; probiotic

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 2 期

页码：

收录情况： SCI

摘要： The search for a natural antimicrobial agent is ongoing and critical because of the rise and rapid proliferation of antibiotic-resistant pathogenic bacteria. The current study aims to examine the effect of Paenibacillus polymyxa AM20 as an alternative antibiotic and feed additive on Indian river broiler per-formance, digestive enzymes, thyroid hormones, lipid profile, hepatosomatic index, immunological response, gut bacteria, and antioxidant parameters. The bacte-rial isolate AM20 was identified at the gene level by isolating DNA and using PCR to detect genes. Based on 16S rRNA gene sequence analysis, the bacterial iso-late was identified as Paenibacillus polymyxa. One hundred twenty Indian river broilers (1-day old) were randomly divided into 4 groups of 10 chicks each, with 3 replicates. The control group was fed a basal diet only, while the other 3 were administered control diets supplemented with P. polymyxa at 3 concentrations: 0.5, 1, and 1.5 mg/kg. The findings revealed that all groups that received graded amounts of P. polymyxa increased all growth parameters throughout the study.P. polymyxa treatment at 1.5 mg/kg increased body gain by 9% compared to the control due to increased feed intake (P = 0.0001), growth rate (P = 0.0001), and decreased feed conversion ratio. Compared to the control group, P. polymyxa (1.5 mg/kg) enhanced kid-ney functions in chickens by reducing uric acid and creatinine levels (P = 0.0451). Compared to the con-trol group, alanine aminotransferase and aspartate transaminase levels in the liver were significantly reduced at all P. polymyxa doses. Liver function values were highest for P. polymyxa at 1.5 mg/kg. Compared to the control group, those whose diets included P. polymyxa had significantly better blood cholesterol levels, high-density lipoprotein, low-density lipopro-tein, immunological response, thyroid function, and gut microbiota. In general, broiler chickens' economic efficiency was improved by including P. polymyxa in their diet, which also improved their growth perfor-mance, carcass dressing, specific blood biochemical levels and enzymes, and the composition of the gut microbiota.