The Hippo-Yki pathway downstream transcription factor Scalloped negatively regulates immune defense against Vibrio parahaemolyticus infection in shrimp
文献类型： 外文期刊
作者： Yang, Linwei 1 ; Han, Deyu 1 ; Wang, Zi-ang 1 ; Chen, Nuo 1 ; Zuo, Hongliang 1 ; Guo, Zhixun 4 ; Xu, Menghuang 1 ; Weng, Shaoping 1 ; He, Jianguo 1 ; Xu, Xiaopeng 1 ;
作者机构： 1.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou, Peoples R China
2.Sun Yat Sen Univ, Southern Marine Sci & Engn Guangdong Lab Zhuhai, Guangzhou, Peoples R China
3.Sun Yat Sen Univ, Inst Aquat Econ Anim, Guangdong Prov Key Lab Aquat Econ Anim, Guangzhou, Peoples R China
4.South China Sea Fisheries Res Inst CAFS, Guangzhou 510300, Peoples R China
5.Sun Yat Sen Univ Guangzhou, Sch Life Sci, Guangzhou 510275, Peoples R China
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）
ISSN： 1050-4648
年卷期： 2023 年 139 卷
页码：
收录情况： SCI
摘要： The Hippo-Yki signaling pathway plays a crucial role in numerous biological processes. Previous studies have demonstrated the significance of signal transduction components of the Hippo pathway in the immune response of shrimp. In this study, the downstream transcription factor of Hippo signaling, Scalloped, was analyzed upregulated in hemocytes. Scalloped was found to localize in the nucleus and interact with the Hippo pathway downstream transcriptional co-activator Yki. With the the NF-& kappa;B family member Dorsal in shrimp. By inhibiting the Dorsal pathway, Scalloped reduced the expression of immune functional proteins and negatively regulated the immune response against bacterial infection in shrimp. RNAi-mediated silencing of Scalloped significantly enhanced the survival rate of V. parahaemolyticus-infected shrimp and reduced the bacterial load in tissues. These findings demonstrate the potential of Scalloped as a therapeutic target for vibriosis in crustaceans and contribute to our understanding of the shrimp's antibacterial defense and the functional roles of Hippo signaling in animal immunity.
- 相关文献
作者其他论文 更多>>
-
Oral delivery of bacteria expressing wsv108 gene-specific dsRNA protects shrimp from white spot syndrome virus (WSSV) infection
作者：Yang, Linwei;Huang, Siyou;Wang, Zi-ang;Han, Deyu;Gan, Yushi;Geng, Ran;Zuo, Hongliang;Weng, Shaoping;He, Jianguo;Xu, Xiaopeng;Yang, Linwei;Huang, Siyou;Wang, Zi-ang;Han, Deyu;Gan, Yushi;Geng, Ran;Zuo, Hongliang;Weng, Shaoping;He, Jianguo;Xu, Xiaopeng;Zuo, Hongliang;Weng, Shaoping;He, Jianguo;Xu, Xiaopeng;Guo, Zhixun;Xu, Xiaopeng
关键词：dsRNA; Oral delivery; White spot syndrome virus
-
Transcriptome profiling of the gills to air exposure in mud crab Scylla paramamosain
作者：Fan, Sigang;Guo, Yihui;Cheng, Changhong;Huang, Xiaolin;Ma, Hongling;Guo, Zhixun;Liu, Guangxin;Gao, Yougen;Fan, Sigang;Huang, Xiaolin;Yang, Qibin;Fan, Sigang;Yang, Qibin;Gao, Yougen
关键词：Scylla paramamosain; Transcriptome; gill; air exposure
-
Antibacterial characterization of Bacillus velezensis LG37 and mining of genes related to biosynthesis of antibacterial substances
作者：Liu, Guangxin;Deng, Yiqin;Cheng, Changhong;Ma, Hongling;Jiang, Jianjun;Feng, Juan;Guo, Zhixun;Liu, Guangxin;Deng, Yiqin;Cheng, Changhong;Ma, Hongling;Jiang, Jianjun;Feng, Juan;Guo, Zhixun
关键词：Bacillus velezensis; bacteriocin; gene cluster; non-ribosomal peptide; ribosomal peptide
-
Hypoxia triggers the proliferation of antibiotic resistance genes in a marine aquaculture system
作者：Deng, Yiqin;Jiang, Jianjun;Huang, Yinbang;Cheng, Changhong;Lin, Ziyang;Liu, Guangxin;Guo, Zhixun;Feng, Juan;Feng, Juan
关键词：Dissolved oxygen; Nutrients; Bacterial community; Horizontal gene transfer; Antibiotic resistance spread
-
The role of Nrf2 signaling pathway in the mud crab (Scylla paramamosain) in response to Vibrio parahaemolyticus infection
作者：Cheng, ChangHong;Ma, HongLing;Liu, GuangXin;Fan, SiGang;Deng, YiQin;Jiang, JianJun;Feng, Juan;Guo, ZhiXun;Guo, ZhiXun
关键词：Mud crab; Nrf2; Immune response; Bacterial challenge
-
Mechanism of Cadmium Exposure Induced Hepatotoxicity in the Mud Crab (Scylla paramamosain): Activation of Oxidative Stress and Nrf2 Signaling Pathway
作者：Cheng, Changhong;Ma, Hongling;Liu, Guangxin;Fan, Sigang;Guo, Zhixun
关键词：Scylla paramamosain; Nrf2 signaling pathway; oxidative stress; hepatotoxicity
-
Bacillus velezensis LG37 absorbs and utilizes ammonia nitrogen from aquaculture water and enhances the toxicity tolerance of grass carp (Ctenopharyngodon idella) to ammonia (non-ionic ammonium)
作者：Liu, Guangxin;Guo, Zhixun;Liu, Guangxin;Guo, Zhixun;Zhao, Lijuan;Lin, Li
关键词：acute toxicity; ammonia; Bacillus velezensis; grass carp; utilization rate
