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Regulatory effects of Glycyrrhiza total flavones on fatty liver injury induced by a high-fat diet in tilapia (Oreochromis niloticus) via the Nrf2 and TLR signaling pathways

文献类型： 外文期刊

作者： Du, Jinliang 1 ; Jia, Rui 1 ; Cao, Liping 1 ; Gu, Zhengyan 4 ; He, Qin 4 ; Xu, Pao 1 ; Yin, Guojun 1 ; Ma, Yuzhong 3 ;

作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resource, Minist Agr & Rural Affairs, Wuxi 214081, Jiangsu, Peoples R China

2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Int Joint Res Lab Fish Immunopharmacol, Wuxi 214081, Jiangsu, Peoples R China

3.Agr Univ Hebei, Coll Vet Med, Baoding 071001, Peoples R China

4.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Jiangsu, Peoples R China

关键词： Glycyrrhiza total flavones; Biochemical indexes; Fat synthesis and metabolism; Tilapia; Signal pathway

期刊名称：AQUACULTURE INTERNATIONAL （ 影响因子：2.953； 五年影响因子：2.94 ）

ISSN： 0967-6120

年卷期： 2022 年 30 卷 3 期

页码：

收录情况： SCI

摘要： Glycyrrhiza total flavones (GTF) have been confirmed to possess anti-oxidation and lipid-lowering effects, but whether they have a protective effect on fatty liver injury in tilapia (Oreochromis niloticus) is unknown. Thus, the aim of this study was to investigate the protective effects of GTF on liver injury induced by a high-fat diet (HFD) and its underlying mechanism in fish. A total of 180 tilapia were randomly divided into four experimental groups: normal control group (basic diet, 6% crude fat), HFD group (fed with HFD, 21% crude fat), and two GTF treatment groups (addition of 0.1 and 1.0 g/kg of GTF to the high-fat diet). After 90 days of feeding, blood and liver tissues were collected to measure biochemical parameters, mRNA levels, and protein expression to evaluate the liver protection of GTF. Compared with the HFD group, addition of GTF to the diet significantly reduced the indexes of liver enzyme activity and fat metabolism in serum. In liver, addition of GTF to the diet upregulated mRNA levels of the oxidative stress-related genes glutathione transferase alpha (GST alpha) and NAD(P)H dehydrogenase (NQO1), and downregulated mRNA level of kelch-like epichlorohydrin-associated protein 1 (Keap1). GTF treatments also significantly reduced mitogen-activated protein kinase 8 (MAPK8) and caspase 3 (CAS-3) protein expression. Meanwhile, GTF treatments downregulated mRNA levels of toll-like receptor1 (TLR1), toll-like receptor5 (TLR5), interleukin 1 receptor-associated kinase (IRAK1), tumor necrosis factor receptor-related factor 6 (TRAF6), complement 3 (C3), heat shock protein 70 (HSP70), and immunoglobulin M (IgM). These results showed that GTF had a well protective effect against fatty liver injury caused by an HFD in tilapia. The beneficial effects of these flavones may be related to changes of nuclear factor-related factor 2 and TLR signaling pathways.

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