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Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis

文献类型： 外文期刊

作者： Wang, Zhou-Ting 1 ; Tang, Yue-Wen 2 ; Wan, Feng 2 ; Yang, Ru-Chun 2 ; Guo, Yan 2 ; Zheng, Jie 2 ; Li, You-Gui 3 ; He, Wei-Ming 1 ;

作者机构： 1.Zhejiang Chinese Med Univ, Sch Life Sci, Hangzhou 310053, Peoples R China

2.Zhejiang Chinese Med Univ, Dept Nephrol, Key Lab Kidney Dis Prevent & Control Technol Zhej, Hangzhou TCM Hosp, Hangzhou 310007, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Sericultural & Tea, Hangzhou 310021, Peoples R China

期刊名称：ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE （ 影响因子：1.7； 五年影响因子：2.5 ）

ISSN： 2221-1691

年卷期： 2023 年 13 卷 8 期

页码：

收录情况： SCI

摘要： Objective: To comparatively investigate the ameliorative effect of Phellinus igniarius (P. igniarius) on renal aging in a rat model of focal and segmental glomerulosclerosis (FSGS). Methods: The FSGS model was established in rats by uninephrectomy combined with tail vein injection of doxorubicin. The FSGS rats were randomly divided into the model group, the P. igniarius decoction group, the P. igniarius polysaccharides group, and the P. igniarius polyphenols group. Molecular indicators of cell senescence, renal function indexes, and podocyte injury markers were tested after ten weeks of intragastric administration. Besides, the pathological renal lesions and the ultrastructural changes were observed. Results: FSGS developed in the model group within ten weeks and showed segmental glomerular scarring and renal aging. Following the 10-week intervention, 24 h proteinuria, serum creatinine, blood urea nitrogen, P16(INK4 alpha), thrombospondin-1, and transforming growth factor-beta 1 were decreased in each treatment group, whereas albumin, erythropoietin, nephrin, and podocin were increased; the pathological renal injury was alleviated, and the number of senescent cells was reduced, especially in rats treated with P. igniarius decoction. Conclusions: P. igniarius ameliorates renal aging and renal injury in the FSGS rat model. Compared with the effective constituents (polysaccharides and polyphenols), P. igniarius decoction has a better curative effect, which is expected to provide a new therapeutic idea for FSGS.

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