The protective effect of Phellinus linteus decoction on podocyte injury in the kidney of FSGS rats
文献类型： 外文期刊
作者： Wan, Feng 1 ; Yang, Ru-chun 1 ; Shi, Yan-peng 1 ; Tang, Yue-Wen 1 ; Tang, Xuan-li 1 ; Zhu, Xiao-ling 1 ; Li, You-gui 2 ;
作者机构： 1.Zhejiang Chinese Med Univ, Guang Xing Hosp, Key Lab Zhejiang Prov Management Kidney Dis, Dept Nephrol, Tiyuchang Rd 453, Hangzhou 310007, Zhejiang, Peoples R China
2.Zhejiang Acad Agr Sci, Sericultural Res Inst, Hangzhou, Zhejiang, Peoples R China
关键词： Phellinus linteus decoction; Protective effect; Podocyte injury; FSGS; Rat
期刊名称：BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE （ 影响因子：3.659； 五年影响因子：3.767 ）
ISSN：
年卷期： 2019 年 19 卷 1 期
页码：
收录情况： SCI
摘要： Background This study aimed to investigate the effect of the Phellinus linteus (Mesima) decoction on podocyte injury in a rat model of focal and segmental glomerulosclerosis (FSGS) and evaluate the potential mechanisms. Methods FSGS resembling primary FSGS in humans was established in rats by uninephrectomy and the repeated injection of doxorubicin. The FSGS rats were randomly divided into the model group, low-dose group of P. linteus decoction (PLD-LD), medium-dose group of P. linteus decoction (PLD-MD), and high-dose group of P. linteus decoction (PLD-HD). Blood and urine analysis were performed after 12 weeks and the molecular indicators of renal function and the renal pathological changes were examined. Results FSGS developed within 12 weeks in the test group and showed progressive proteinuria and segmental glomerular scarring. Urinary protein, serum creatinine, urea nitrogen, triglycerides and cholesterol were significantly reduced following the 12-week intervention with P.linteus decoction, especially in the PLD-LD group. Renal nephrin and podocin were markedly increased. Moreover, the pathological damage in the renal tissue was alleviated by the PLD-LD intervention. Conclusion The P. linteus decoction alleviated the podocyte injury in the FSGS rat model, thus minimizing the progression of glomerular sclerosis and improving renal function.
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