Design, Synthesis and Bioactivity of Novel 2-Phenylethanol Ester Derivatives Containing Monoterpene Fragments
文献类型： 外文期刊
作者： Pan, Shixiang 1 ; Liu, Yan 1 ; Shi, Zhuo 1 ; Lu, Xingxing 1 ; Qin, Yaoguo 2 ; Qu, Cheng 3 ; Chen, Chen 1 ; Yang, Xinling 1 ;
作者机构： 1.China Agr Univ, Coll Sci, Dept Appl Chem, Beijing 100193, Peoples R China
2.China Agr Univ, Coll Plant Protect, Dept Entomol, Beijing 100193, Peoples R China
3.Beijing Acad Agr & Forestry Sci, Inst Plant Protect, Beijing 100097, Peoples R China
关键词： 2-phenylethanol; odorant binding protein; repel aphid; attract ladybug; eco-friendliness
期刊名称：CHINESE JOURNAL OF ORGANIC CHEMISTRY （ 影响因子：2.2； 五年影响因子：1.5 ）
ISSN： 0253-2786
年卷期： 2025 年 45 卷 1 期
页码：
收录情况： SCI
摘要： To discover novel aphid control agents, taking plant volatile 2-phenylethanol as a lead, 16 ester derivatives of 2-phenylethanol containing monoterpenoid fragments were designed and synthesized by the method of active substructure splicing. The binding affinity of target compounds to odorant binding proteins (OBP) of Acyrthosiphon pisum and Harmonia axyridis was measured via fluorescent competitive binding assay. All compounds showed good binding affinity to both proteins, better than 2-phenylethanol. Behavioral experiments showed that all target compounds had repelling activity against A. pisum (35.9%similar to 57.7%) with 3-methoxyphenethyl (E)-3,7-dimethylocta-2,6-dienoate (3f) exhibiting the best repellency. In addition, 3f also showed significant attractive activity to H. axyridis. The binding mode of 3f with the OBP protein was investigated by molecular docking, revealing that the introduction of the monoterpenoid fragment significantly enhanced the hydrophobic interactions between compounds and proteins. Preliminary toxicity tests indicated that 3f was safe to H. axyridis, showing great application prospects in the green control of aphids.
- 相关文献
作者其他论文 更多>>
-
Yes-associated protein 1 is essential for maintaining lactation via regulating mammary epithelial cell dynamics and secretion capacity
作者：Lv, Haimiao;Wu, Zihui;Lin, Yuxin;Liu, Miaoyu;Xu, Linghua;Wang, Xiaojie;Sun, Nan;Abdelrahman, Mohamed;Yang, Liguo;Hua, Guohua;Lv, Haimiao;Hua, Guohua;Lv, Haimiao;Hua, Guohua;Xu, Xiaoling;Liu, Yan;Abdel-Shafy, Hamdy;Abdelrahman, Mohamed;Alsaegh, Aiman A.;Ahmed, Ahmed Ezzat;Ahmed, Ahmed Ezzat;Yang, Liguo;Hua, Guohua
关键词：Lactation; Yes-associated protein1(YAP1); Prolactin; Melatonin; Mammary epithelial cells
-
Sublethal and transgenerational effects of tetraniliprole on the tomato pinworm Phthorimaea (=Tuta) absoluta (Lepidoptera: Gelechiidae)
作者：Yao, Jiaqi;Wang, Yuguang;Yao, Jiaqi;Wang, Yuguang;Yao, Jiaqi;Qu, Cheng;Li, Yunyi;Luo, Chen;Wang, Ran;Guedes, Raul Narciso C.
关键词：Phthorimaea absoluta; Tetraniloprole; Transgenerational sublethal effects; Vitellogenin; Vitellogenin receptor; Antioxidant enzymes
-
Involvement of the cytochrome P450 genes CYP6DW3 and CYP4C64 in afidopyropen resistance in Bemisia tabaci Mediterranean (Q biotype)
作者：Ma, Lijun;Luo, Chen;Tang, Juan;Zhang, Qinghe;Gao, Bingli;Qu, Cheng;Wang, Ran
关键词：Bemisia tabaci; afidopyropen; insecticide detoxification; cytochrome P450 monooxygenase
-
Effects of cloprostenol sodium and carbetocin on synchronous parturition and colostrum composition in large white sows
作者：Gao, Hongmei;Zhang, Longchao;Wang, Dong;Wang, Lixian;Peng, Miaolian;Zhong, Rongzhi;Xue, Zhenhua;Liu, Zhenqiang;Weng, Shiqiao;Liu, Yan;Tian, Jianhui;Tian, Jianhui;Tian, Jianhui
关键词：Cloprostenol sodium; Carbetocin; Large white sows; Farrowing induction; Colostrum
-
Baseline susceptibility, risk assessment, biochemical mechanism and fitness cost of broflanilide resistance in Tuta absoluta from China
作者：Qu, Cheng;Lin, Ao-li;Wang, Ze-hua;Feng, Yao-fang;Luo, Chen;Wang, Ran;Qu, Cheng;Wang, Ze-hua;Luo, Chen;Wang, Ran;Lin, Ao-li;Fang, Yong;Wang, Ran;Guedes, Raul Narciso C.
关键词：tomato pinworm; toxicity; field-evolved resistance; resistance risk; detoxifying enzymes
-
Alterations to the vaginal microbiota and their correlation with serum pro-inflammatory cytokines in post-weaning sows with endometritis
作者：Xian, Tingting;Cao, Xin;Xian, Tingting;Liu, Yan;Feng, Tao;Xian, Tingting;Liu, Yan;Feng, Tao
关键词：Post-weaning sows; Endometritis; Cytokines; 16S rDNA sequencing; Vaginal mucus microflora
-
Editing Plant Volatile Isoeugenol for Integrated Aphid Management: Discovering Ecofriendly Insect Behavioral Regulators with Push-Pull Activity Targeting Odorant-Binding Proteins
作者：Liu, Yan;Chen, Chen;Zhang, Yimeng;Huang, Jiachuan;Pan, Shixiang;Yang, Zhaokai;Shi, Zhuo;Yang, Xinling;Qu, Cheng;Huang, Yiwen;Qin, Yaoguo;Huang, Yiwen;Qin, Yaoguo;Li, Xuesheng
关键词：insect behavioral regulator; "push-pull"strategy; odorant-binding proteins; ecofriendlybotanical derivatives; molecular docking; densityfunctional theory
