Editing Plant Volatile Isoeugenol for Integrated Aphid Management: Discovering Ecofriendly Insect Behavioral Regulators with Push-Pull Activity Targeting Odorant-Binding Proteins
文献类型： 外文期刊
作者： Liu, Yan 1 ; Chen, Chen 1 ; Qu, Cheng 2 ; Zhang, Yimeng 1 ; Huang, Jiachuan 1 ; Pan, Shixiang 1 ; Yang, Zhaokai 1 ; Shi, Zhuo 1 ; Huang, Yiwen 3 ; Qin, Yaoguo 3 ; Li, Xuesheng 5 ; Yang, Xinling 1 ;
作者机构： 1.China Agr Univ, Coll Sci, Innovat Ctr Pesticide Res, Dept Appl Chem, Beijing 100193, Peoples R China
2.Beijing Acad Agr & Forestry Sci, Inst Plant Protect, Beijing 100097, Peoples R China
3.China Agr Univ, Coll Plant Protect, Dept Entomol, Beijing 100193, Peoples R China
4.China Agr Univ, Coll Plant Protect, MOA Key Lab Monitoring & Environm Friendly Control, Beijing 100193, Peoples R China
5.Guangxi Univ, Agr Coll, Guangxi Key Lab Agroenvironm & Agroprod Safety, Nanning 530004, Guangxi, Peoples R China
关键词： insect behavioral regulator; "push-pull"strategy; odorant-binding proteins; ecofriendlybotanical derivatives; molecular docking; densityfunctional theory
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）
ISSN： 0021-8561
年卷期： 2025 年 73 卷 33 期
页码：
收录情况： SCI
摘要： Chemical ecology-based insect behavioral regulation approaches, particularly the "push-pull" strategy, hold tremendous potential for sustainable pest management. Odorant-binding proteins (OBPs) are key targets for regulating insect behavior, whereas plant volatile organic compounds function as key semiochemicals. A series of isoeugenol derivatives were rationally edited by targeting Acyrthosiphon pisum OBP9 and Harmonia axyridis OBP15 for discovering botanical-based insect behavioral regulators. Most derivatives demonstrated significantly higher target binding activity than isoeugenol, with compound I-10 showing exceptional bioactivity. I-10 displayed excellent A. pisum-repellent and H. axyridis-attractive activities. Molecular mechanism studies established the superior binding ability of I-10 to both OBPs via hydrophobic interactions, with its high chemical softness, large hydrophobic surface area, and extensive charge distribution contributing to its bioactivity. Importantly, I-10 showed favorable biosafety for honeybees, ladybugs, parasitic wasps, and plants. This study provides novel insights for developing ecofriendly candidates with push-pull activity by targeting OBPs for integrated aphid management.
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