文献类型： 外文期刊
作者： Cheng, Jia 1 ; Yang, Ling 3 ; Wang, Shiping 2 ; Luo, Kaiyong 1 ; Luo, Senlin 1 ; Dong, Yang 2 ; Ning, Ya 4 ; Wang, Weibin 2 ;
作者机构： 1.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Yunnan Prov Key Lab Biol Big Data, Kunming 650201, Peoples R China
3.Hainan Acad Agr Sci, Inst Agroprod Proc & Design, Haikou 571100, Peoples R China
4.Yunnan Agr Univ, Coll Sci, Kunming 650201, Peoples R China
关键词： RSPO gene family; molecular evolution; phylogenetic analysis; the enhancer of Wnt signaling
期刊名称：GENES （ 影响因子：2.8； 五年影响因子：3.2 ）
ISSN：
年卷期： 2025 年 16 卷 5 期
页码：
收录情况： SCI
摘要： Background: The RSPO gene family encodes secreted glycoproteins that are rich in cysteine, which generally serve as activators of the Wnt signaling pathway in animals. Four types of this family have been identified in a few model species. However, the evolution of the family remains unclear. Methods: In this study, we identified a total of 1496 RSPO homologs through an extensive survey of the RSPO genes in 430 animals. Gene family clustering and phylogenetic analysis identified four major subtypes of the family (RSPO1-RSPO4) and clarified their distribution of copy number in different species. Results and Conclusions: Members of the RSPO4 subfamily that were closest to ancestral forms existed in both Deuterostomes and Protostomates, and we speculate that representatives of this subfamily already existed in Urbilatera, the last common ancestor of Deuterostomes. Particularly, in some RSPO3 subtypes of Actinopterygii (ray-finned fishes), an FU repeated motif with three conserved cysteines was identified. Further conservative analysis of amino acids and alignment of tertiary protein structure revealed the potential functional sites for each subgroup. The results provide insight into the phylogenetic relationships and evolutionary patterns of conserved motifs of RSPO family genes in animal kingdoms, which will guide further studies on the biological functions of RSPO in other non-model species.
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