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Process optimization and character evaluation of Bletilla striata polysaccharide (BSP) and chitosan (CS) composite hemostatic sponge (BSP-CS)

文献类型： 外文期刊

作者： Zhang, Yeshan 1 ; Han, Xue 2 ; Zhao, Jun 3 ; Gan, Menglan 4 ; Chen, Yaya 2 ; Zhang, Jinxia 2 ; He, Yu 1 ; Wu, Mingkai 2 ; Liu, Hai 2 ;

作者机构： 1.Guizhou Univ, Inst Agrobioengn, Key Lab Plant Resource Conservat & Germplasm Innov, Minist Educ,Coll Life Sci, Guiyang 550025, Guizhou, Peoples R China

2.Guizhou Acad Agr Sci, Inst Modern Chinese Herbal Med, Guizhou Inst Crop Variety Resources, Guizhou Engn Res Ctr Cultivat & Planting Chinese M, Guiyang 550006, Peoples R China

3.Guizhou Tongde Pharmaceut Co Ltd, Tongren 554300, Guizhou, Peoples R China

4.Guizhou Vocat Coll Agr, Guiyang 551400, Guizhou, Peoples R China

期刊名称：BIOINTERPHASES （ 影响因子：2.1； 五年影响因子：2.2 ）

ISSN： 1934-8630

年卷期： 2024 年 19 卷 2 期

页码：

收录情况： SCI

摘要： Bletilla striata polysaccharide (BSP) and chitosan (CS) were chemically cross-linked using oxalyl chloride to prepare a composite hemostatic sponge (BSP-CS), and the process parameters were optimized using the Box-Behnken design (BBD) with response surface methodology. To optimize the performance of the hemostatic sponge, we adjusted the ratio of independent variables, the amount of oxalyl chloride added, and the freeze-dried volume. A series of evaluations were conducted on the hemostatic applicability of BSP-CS. The characterization results revealed that BSP-CS had a stable bacteriostatic effect on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa within 72 h, and the bacteriostatic rate was above 30%. The CCK-8 cytotoxicity test demonstrated that BSP-CS had a certain effect on promoting cell proliferation of L929 cells. In the mouse tail-cutting experiment, the hemostasis time of BSP-CS was 463.0 +/- 38.16 s, shortened by 91.3 s on average compared with 554.3 +/- 34.67 s of the gauze group. The blood loss of the BSP-CS group was 28.47 +/- 3.74 mg, which was 34.7% lower than that of the control gauze group ( 43.6 +/- 3.83 mg). In the in vitro coagulation experiment, the in vitro coagulation index of the BSP-CS group was 97.29 % +/- 1.8 %, which was reduced to 8.6% of the control group. The CT value of the BSP-CS group was 240 +/- 15 s, which was 155 s lower than that of the gauze group ( 355 +/- 31.22 s). All characterization results indicate that BSP-CS is an excellent hemostatic material.

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