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Revelation of benzo(a)pyrene-induced latent toxicity mechanism to intestinal histomorphology and oxidative status for common carp (Cyprinus carpio) through transcriptional and single-cell sequencing

文献类型： 外文期刊

作者： Hao, Qirui 1 ; Chen, Zhongxiang 1 ; Fan, Ze 1 ; Wu, Song 1 ; Bai, Shuyan 1 ; Du, Ningning 1 ; Li, Chenhui 1 ; Wang, Peng 1 ; Zhao, Rongwei 6 ; Huang, Li 1 ; Gao, Lei 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin 150070, Peoples R China

2.Minist Agr & Rural Affairs, Key Lab Control Qual & Safety Aquat Prod, Beijing 100141, Peoples R China

3.Minist Agr & Rural Affairs, Supervis Inspect & Testing Ctr Fishery Environm &, Harbin 150070, Peoples R China

4.Minist Agr & Rural Affairs, Lab Qual & Safety Risk Assessment Aquat Prod Harbi, Harbin 150070, Peoples R China

5.Key Lab Aquat Anim Dis & Immune Technol Heilongjia, Harbin 150070, Peoples R China

6.Harbin Agr Technol Extens Master Stn, Harbin 150028, Peoples R China

关键词： Benzo( a )pyrene exposure; Common carp; GSH signaling pathway; ADP signaling pathway; Lysosome-phagosome pathway; Myeloid cells

期刊名称：AQUACULTURE （ 2022影响因子：4.5； 五年影响因子：4.6 ）

ISSN： 0044-8486

年卷期： 2024 年 585 卷

页码：

收录情况： SCI

摘要： Common carp (Cyprinus carpio) (mean weight 50.0 +/- 10.0 g) were exposed for 15 d with benzo[a]pyrene (B[a]P) concentrations of 0, 2.5 and 25 mu g/kg in the water. For markers of oxidative stress, intestinal contents of glutathione (GSH) and malondialdehyde and activities of catalase and superoxide dismutase were significantly elevated after 15-d B[a]P exposure. For intestinal histology and ultrastructure analysis, intestinal histiocytes not only swelled, but also intensified blood aggregation, resulting in hematoma after exposed to high B[a]P concentration. For intestinal transcriptome response, GSH signaling pathway was abnormally activated after exposure to B[a]P, thereby resulting in intestinal oxidative damage. Meanwhile, exposure to B[a]P suppressed intestinal platelet activation depending on ADP signaling pathway. Exposure to high B[a]P concentration induced intestinal cellular edema through the suppression of Lysosome-Phagosome pathway. For scRNA-seq results, myeloid cells under B[a]P stress, despite having evolved into cell types with distinct specialties, still retained innate immune functions such as Macrophage_3. The present study provides valuable and front-edged insights for developing sustainable solutions to address the challenges posed by PAHs waste and B[a]P contamination on aquaculture system.

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