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Effects of L-theanine on intestinal morphology, barrier function, and MAPK signaling pathways in diquat-challenged piglets

文献类型： 外文期刊

作者： Liu, Zhengqun 1 ; Li, Zeqing 3 ; Zheng, Zi 1 ; Li, Ning 1 ; Mu, Shuqin 1 ; Ma, Yong 1 ; Zhou, Zhijiang 4 ; Yan, Jun 1 ; Lu, Chunlian 5 ; Wang, Wenjie 1 ; Zhang, Hongfu 2 ;

作者机构： 1.Tianjin Acad Agr Sci, Inst Anim Sci & Vet, Tianjin, Peoples R China

2.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R China

3.Tianjin Agr Dev Serv Ctr, Tianjin, Peoples R China

4.Tianjin Univ, Coll Chem Engn, Tianjin, Peoples R China

5.Hebei Agr Univ, Coll Anim Sci & Technol, Baoding, Peoples R China

关键词： L-theanine; weaned piglet; oxidative stress; growth performance; intestinal health

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.141； 五年影响因子：1.92 ）

ISSN： 1049-5398

年卷期：

页码：

收录情况： SCI

摘要： This study aimed to explore the protective effects of L-theanine supplementation on the diquat-challenged weaned piglets. A total of 160 weaned piglets were randomly divided into 4 groups using a 2 x 2 two-factor design, there were 4 replicates per group and 10 pigs per replicate. Piglets were fed diets (with 1000 mg/kg L-theanine addition or not), then challenged with diquat or saline on day 7. 21 days after challenge, two pigs from each replicate were selected for sample collection. Results showed that supplement with 1000 mg/kg L-theanine down-regulated the diarrhea rate, serum D-lactate level, tumor necrosis factor-alpha, and phosphorylation of extracellular regulated protein kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK) signaling in pigs without diquat challenge (p < 0.05). While for diquat-challenged piglets, L-theanine addition increased average daily gain, jejunum villus height, and interferon-gamma level (p < 0.05). Meanwhile, L-theanine addition decreased the diarrhea rates and mortality, serum D-lactate level, and phosphorylation of ERK and JNK in diquat-challenged pigs (p < 0.05). These results demonstrate that L-theanine pretreatment could alleviate diquat-induced oxidative stress and improve intestinal barrier function in diquat-challenged weaned piglets, which can be attributed to suppression of MAPK phosphorylation signaling pathways.

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[1]Effects of L-theanine on intestinal morphology, barrier function, and MAPK signaling pathways in diquat-challenged piglets. Liu, Zhengqun,Zheng, Zi,Li, Ning,Mu, Shuqin,Ma, Yong,Yan, Jun,Wang, Wenjie,Liu, Zhengqun,Yan, Jun,Zhang, Hongfu,Li, Zeqing,Zhou, Zhijiang,Yan, Jun,Lu, Chunlian.

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