Hepatoprotective effects of Niudali (Callerya speciosa) root aqueous extracts against tetrachloromethane-induced acute liver injury and inflammation
文献类型： 外文期刊
作者： Zhang, Yizi 1 ; Huang, Jinwen 1 ; Gan, Lishe 1 ; Wu, Rihui 1 ; Jin, Jingwei 1 ; Wang, Tinghan 3 ; Sun, Shili 4 ; Zhang, Zhenbiao 4 ; Li, Liya 5 ; Zheng, Xi 1 ; Zhang, Kun 1 ; Sun, Lingli 4 ; Ma, Hang 1 ; Li, Dongli 1 ;
作者机构： 1.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China
2.Int Healthcare Innovat Inst Jiangmen, Jiangmen, Peoples R China
3.Univ Rhode Isl, Coll Pharm, Bioact Bot Res Lab, Biomed & Pharmaceut Sci, Kingston, RI USA
4.Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Key Lab Tea Resources Innovat & Utilizat, Guangzhou 510640, Peoples R China
5.Northeastern Univ, Inst Microbial Pharmaceut, Coll Life & Hlth Sci, Shenyang, Peoples R China
关键词： anti-inflammation; antioxidant; Callerya speciosa; hypaphorine; liver protection; polysaccharides
期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：3.9； 五年影响因子：4.1 ）
ISSN： 2048-7177
年卷期： 2023 年
页码：
收录情况： SCI
摘要： Niudali (Callerya speciosa) is commonly grown in southeastern regions of China and consumed as a food ingredient. Although Niudali root extracts showed various biological activities, the hepatoprotective effects of Niudali root phytochemicals are not fully studied. Herein, we prepared two Niudali root aqueous extracts, namely, c and Niudali polysaccharides-enriched extract (NPE), and identified an alkaloid, (hypaphorine) in NEW. The hepatoprotective effects of NWE, NPE, and hypaphorine were evaluated in an acute liver injury model induced by carbon tetrachloride (CCl4) in mice. Pathohistological examination and blood chemistry assays showed that treatment of NWE, NPE, and hypaphorine alleviated CCl4-induced liver damage by lowering the liver injury score (by 75.51%, 80.01%, and 41.22%) and serum aspartate and alanine transaminases level (by 63.24%, 85.22%, and 49.74% and by 78.73%, 80.08%, and 81.70%), respectively. NWE, NPE, and hypaphorine also reduced CCl4-induced hepatic oxidative stresses in the liver tissue by decreasing the levels of malondialdehyde (by 40.00%, 51.25%, and 28.75%) and reactive oxygen species (by 30.22%, 36.14%, and 33.54%) while increasing the levels of antioxidant enzymes including superoxide dismutase (by 21.36%, 21.64%, and 8.90%), catalase (by 22.13%, 33.33%, and 5.39%), and glutathione (by 84.87%, 90.65%, and 80.53%), respectively. Mechanistic assays showed that NWE, NPE, and hypaphorine alleviated liver damage by mediating inflammatory biomarkers (e.g., pro-inflammatory cytokines) via the signaling pathways of mitogen-activated protein kinases and nuclear factor-?B. Findings from our study extend the understanding of Niudali's hepatoprotective effects, which is useful for its development as a dietary intervention for liver inflammation.
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