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Bile acids and their receptors in regulation of gut health and diseases

文献类型： 外文期刊

作者： Lin, Sen 1 ; Wang, Sutian 3 ; Wang, Peng 4 ; Tang, Cuiming 2 ; Wang, Zhenjiang 2 ; Chen, Lian 2 ; Luo, Guoqing 2 ; Chen, Hong 5 ; Liu, Yuntao 5 ; Feng, Bin 5 ; Wu, De 1 ; Burrin, Douglas G. 6 ; Fang, Zhengfeng 1 ;

作者机构： 1.Sichuan Agr Univ, Anim Nutr Inst, Key Lab Anim Dis Resistance Nutr, Minist Educ, Chengdu 611130, Peoples R China

2.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Key Lab Urban Agr South China, Guangzhou 510640, Peoples R China

3.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding, Guangdong Key Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China

4.Henan Univ Technol, Coll Biol Engn, Zhengzhou 450001, Peoples R China

5.Sichuan Agr Univ, Coll Food Sci, Key Lab Food Sci & Human Hlth, Yaan 625014, Peoples R China

6.Baylor Coll Med, USDA ARS Childrens Nutr Res Ctr, Dept Pediat, Houston, TX 77030 USA

关键词： Bile acids; FXR; GPBAR1; Inflammatory bowel diseases; Colorectal cancers

期刊名称：PROGRESS IN LIPID RESEARCH （ 2022影响因子：13.6； 五年影响因子：16.1 ）

ISSN： 0163-7827

年卷期： 2023 年 89 卷

页码：

收录情况： SCI

摘要： It is well established that bile acids play important roles in lipid metabolism. In recent decades, bile acids have also been shown to function as signaling molecules via interacting with various receptors. Bile acids circulate continuously through the enterohepatic circulation and go through microbial transformation by gut microbes, and thus bile acids metabolism has profound effects on the liver and intestinal tissues as well as the gut microbiota. Farnesoid X receptor and G protein-coupled bile acid receptor 1 are two pivotal bile acid receptors that highly expressed in the intestinal tissues, and they have emerged as pivotal regulators in bile acids metabolism, innate immunity and inflammatory responses. There is considerable interest in manipulating the metabolism of bile acids and the expression of bile acid receptors as this may be a promising strategy to regulate intestinal health and disease. This review aims to summarize the roles of bile acids and their receptors in regulation of gut health and diseases.

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