Isolation, structure elucidation and apoptosis-inducing activity of new compounds from the edible fungus Lentinus striguellus
文献类型： 外文期刊
作者： Zheng, Yongbiao 1 ; Zhao, Baobing 1 ; Lu, Chunhua 1 ; Lin, Xinjian; Zheng, Zhonghui 1 ; Su, Wenjin 1 ;
作者机构： 1.Xiamen Univ, Minist Educ Cell Biol & Tumor Cell Engn, Xiamen Engn Res Ctr Marine Microbial Drug Discove, Fujian Engn Lab Pharmaceut,Sch Life Sci,Key Lab, Xiamen 361005, Fujian, Peoples R China
2.Fujian Acad Agr Sci, Inst Soil & Fertilizer, Fuzhou 35
关键词： Apoptosis activity;Lentinus striguellus;Striguellol A;Striguellolide A;Striguellone A
期刊名称：NATURAL PRODUCT COMMUNICATIONS （ 影响因子：0.986； 五年影响因子：1.068 ）
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收录情况： SCI
摘要： Three new natural compounds, striguellolide A (1), striguellol A (2) and striguellone A (6), together with three known ones, 3,4-trans-dihydroxy-6- methoxy-2,2-dimethylchroman (3), 3-hydroxy-6- methoxy-2,2-dimethylchroman-4-one (4) and 3-hydroxy-6- methoxy-2,2-dimethylchroman (5), were isolated from the agar cultures of the edible fungal strain Lentinus striguellus. Their structures were elucidated by spectroscopic and mass spectrometric analyses, including 1D-, 2D-NMR and HR-ESI-Q-TOF-MS, and chemical reactions. Striguellone A showed cytotoxicity against HeLa cells by MTT assay and was found to be an activator of apoptosis, assessed by morphological observation and cell cycle analysis using the flow cytometer.
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