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Application of a novel phage LPCS28 for biological control of Cronobacter sakazakii in milk and reconstituted powdered infant formula

文献类型： 外文期刊

作者： Zou, Geng 1 ; Ndayishimiye, Libere 1 ; Xin, Lingxiang 2 ; Cai, Manshan 1 ; Zhang, Longjian 1 ; Li, Jie 4 ; Song, Zhiyong 5 ; Wu, Renwei 1 ; Zhou, Yang 4 ; Shi, Yuanguo 6 ; Ye, Yingwang 7 ; Zhou, Rui 1 ; Li, Jinquan 1 ;

作者机构： 1.Huazhong Agr Univ, Shenzhen Inst Nutr & Hlth, Coll Food Sci & Technol, Coll Biomed & Hlth,Key Lab Environm Correlat Dieto, Wuhan 430070, Hubei, Peoples R China

2.China Inst Vet Drug Control, Beijing 100086, Peoples R China

3.Guangdong Key Lab Anim Breeding & Nutr, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding, Guangzhou 510640, Peoples R China

4.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

5.Huazhong Agr Univ, Coll Sci, Wuhan 430070, Hubei, Peoples R China

6.Shenzhen Inst Qual & Safety Inspection & Res, Shenzhen 518000, Peoples R China

7.Hefei Univ Technol, Sch Food Sci & Bioengn, Hefei 230009, Anhui, Peoples R China

8.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr, Shenzhen Branch,Guangdong Lab Lingnan Modern Agr,G, Shenzhen 518000, Peoples R China

9.Rockefeller Univ, Lab Bacterial Pathogenesis & Immunol, New York, NY 10065 USA

10.Huazhong Agr Univ, Coll Biomed & Hlth, Wuhan 430070, Hubei, Peoples R China

关键词： Cronobacter sakazakii; Phage; Powdered infant formula; Biological control; Thermal processing; Milk

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.1； 五年影响因子：7.7 ）

ISSN： 0963-9969

年卷期： 2023 年 172 卷

页码：

收录情况： SCI

摘要： Contamination of infant formula with Cronobacter sakazakii (C. sakazakii) can cause fatal infections in neonates. Phages have emerged as promising antibacterial agents for food safety, but their effectiveness may be limited by thermal processing. In this study, we isolated 27 C. sakazakii phages from environmental water samples and selected LPCS28 due to its broad lysis spectrum. The titer of LPCS28 will not be significantly affected by heating at a temperature of 60 degrees C for one hour. In both reconstituted powdered infant formula (RPIF) and liquid milk, the pre-added LPCS28, after the thermal processing at 63 degrees C for 30 min, significantly inhibited the postcontaminated C. sakazakii (103 CFU/mL) and eventually reduced the number of C. sakazakii to below the limit of detection (<10 CFU/mL) within 9 h at 37 C and significantly delayed the increase of bacterial concentration in the samples at 23 degrees C. The phylogenetic analysis revealed that LPCS28 belonged to a new genus, we proposed as Nanhuvirus, under the family Straboviridae. These findings suggest that phage LPCS28 is a promising biological control agent for pathogenic C. sakazakii in the dairy industry.

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