Lactobacillus plantarum 17-5 attenuates Escherichia coli-induced inflammatory responses via inhibiting the activation of the NF-kappa B and MAPK signalling pathways in bovine mammary epithelial cells
文献类型： 外文期刊
作者： Li, Ke 1 ; Yang, Ming 1 ; Tian, Mengyue 2 ; Jia, Li 1 ; Du, Jinliang 1 ; Wu, Yinghao 1 ; Li, Lianmin 1 ; Yuan, Lining 1 ; Ma, Yuzhong 1 ;
作者机构： 1.Hebei Agr Univ, Coll Vet Med, Baoding 071001, Hebei, Peoples R China
2.Hebei Univ Engn, Coll Life Sci & Food Engn, Handan 056038, Hebei, Peoples R China
3.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resource, Minist Agr, Wuxi 214081, Jiangsu, Peoples R China
关键词： Lactobacillus plantarum; Escherichia coli; Inflammation; NF-kappa B; MAPK; Bovine mammary epithelial cell
期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.792； 五年影响因子：3.008 ）
ISSN：
年卷期： 2022 年 18 卷 1 期
页码：
收录情况： SCI
摘要： Background: Mastitis is one of the most prevalent diseases and causes considerable economic losses in the dairy farming sector and dairy industry. Presently, antibiotic treatment is still the main method to control this disease, but it also brings bacterial resistance and drug residue problems. Lactobacillus plantarum (L. plantarum) is a multifunctional probiotic that exists widely in nature. Due to its anti-inflammatory potential, L. plantarum has recently been widely researched in complementary therapies for various inflammatory diseases. In this study, the apoptotic ratio, the expression levels of various inflammatory mediators and key signalling pathway proteins in Escherichia coli-induced bovine mammary epithelial cells (BMECs) under different doses of L. plantarum 17-5 intervention were evaluated. Results: The data showed that L. plantarum 17-5 reduced the apoptotic ratio, downregulated the mRNA expression levels of TLR2, TLR4, MyD88, IL1 beta, IL6, IL8, TNF alpha, COX2, iNOS, CXCL2 and CXCL10, and inhibited the activation of the NF-kappa B and MAPK signalling pathways by suppressing the phosphorylation levels of p65, I kappa B alpha, p38, ERK and JNK. Conclusions: The results proved that L. plantarum 17-5 exerted alleviative effects in Escherichia coli-induced inflammatory responses of BMECs.
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