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Short-term cold stress can reduce the abundance of antibiotic resistance genes in the cecum and feces in a pig model

文献类型： 外文期刊

作者： Yang, Yiwen 1 ; Chen, Ningxue 1 ; Sun, Lan 1 ; Zhang, Yu 1 ; Wu, Yinbao 1 ; Wang, Yan 1 ; Liao, Xindi 1 ; Mi, Jiandui 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Peoples R China

2.South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind, Guangzhou 510642, Peoples R China

3.South China Agr Univ, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Peoples R China

4.South China Agr Univ, Key Lab Trop Agr Environm, Minist Agr, Guangzhou 510642, Peoples R China

关键词： Cold stress; Antibiotic resistance genes (ARGs); Cecum; Feces; Pig

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：10.588； 五年影响因子：10.129 ）

ISSN： 0304-3894

年卷期： 2021 年 416 卷

页码：

收录情况： SCI

摘要： Comprehensive studies on the effects of cold stress on antibiotic resistance genes (ARGs) in the intestines and feces remain scarce. In this study, pigs were selected as the animal model and divided into a normal temperature group and a 48-h short-term cold stress group. The ARG profiles in fecal, cecal content and cecal mucosa samples were analyzed. The results showed that the normalized abundance of ARGs in the cecal mucosa samples in the cold stress group was significantly higher than that in the normal temperature group, while the normalized ARG abundances in the fecal and cecal content samples were significantly lower than those in the normal temperature group (P < 0.05). The bacterial community composition (especially Firmicutes) was the major driver impacting the ARG profile and accounted for 32.2% of the variation in the ARG profile, followed by metabolites (especially creatinine and oxypurinol) and mobile genetic elements (MGEs) (especially plasmids and insertion elements). And it was found that creatinine and oxypurinol can reduce the abundance of ARGs and Firmicutes in the in vitro experiment. The results indicate that short-term cold stress can reduce the abundance of ARGs in the cecum and feces of pigs, providing reference data for environmental safety.

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