文献类型： 外文期刊

作者： Shabbir, Samina ¹ ; Boruah, Prerona ³ ; Kulyar, Muhammad Fakhar-e-Alam ⁴ ; Bhutta, Zeeshan Ahmad ⁵ ; Nawaz, Mohsin ⁶ ; Ashar, Ambreen ⁷ ; Mahfooz, Ashar ⁸ ; Khan, Muhammad Saleem ⁹ ; Miao, Xiangyang ¹ ; Jabeen, Farhat ⁹ ; Mengal, Kifayatullah ¹⁰ ;

作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

2.Guangdong Acad Agr Sci, Inst Plant Protect, Guangzhou 510640, Guangdong, Peoples R China

3.DY Patil Univ, Sch Biotechnol & Bioinformat, Navi Mumbai 400614, India

4.Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China

5.Chungbuk Natl Univ, Coll Vet Med, Lab Biochem & Immunol, Cheongju 28644, Chungbuk, South Korea

6.Hainan Univ, Minist Educ, Coll Forestry, Key Lab Genet & Germplasm Innovat Trop Special For, R China, Haikou 570228, Peoples R China

7.Univ Agr Faisalabad, Dept Chem, Faisalabad 38000, Pakistan

8.Univ Agr Faisalabad, Dept Clin Med & Surg, Faisalabad 38000, Pakistan

9.Univ Okara, Fac Life Sci, Dept Zool, Okara 56130, Punjab, Pakistan

10.Univ South Bohemian Ceske Budejouvice, South Bohemia Res Ctr Aquaculture & Biodivers Hydr, Ceske Budejouvice, Czech Republic

关键词： Nanoparticles; nephrotoxicity; Cinnamomum cassia; Azadirachta indica; TiO2; histology; nanotechnology

期刊名称：CURRENT NANOSCIENCE （ 影响因子：1.5； 五年影响因子：1.4 ）

ISSN： 1573-4137

年卷期： 2023 年 19 卷 2 期

页码：

收录情况： SCI

摘要： Introduction: Titanium Dioxide (TiO2) has gained a lot of focus in today's world owing to its wide usage in several industries. The hazardous effects of TiO2 and its nanoparticles are also slowly revealing. The need for a proper cure of these toxic effects is of utmost importance. Due to its few side effects, medicinal plants can be an efficient source of remedy but are least considered compared to synthetic medicines. Cinnamomum cassia and Azadirachta indica are the most common of such medicinal plants used extensively in Pakistan and India. In this study, we carried out experiments to know the toxic effects of TiO2 nanoparticles in kidneys using a murine model and observed the ameliorating effects of Cinnamomum cassia and Azadirachta indica on the toxicity of TiO2 nanoparticles. Methods: Rats were given a subcutaneous injection of TiO2 nanoparticles at the dose of 150mg/kg body weight for 28 days along with oral administration of Cinnamomum cassia and Azadirachta indica alone and in combination. Results and Discussion: Both Cinnamomum cassia and Azadirachta indica at doses of 100 or 150mg/kg reduced the toxic effects of TiO2 nanoparticles evident from reduced alterations in kidney histopathology and also decreased DNA damage. Conclusion: It was concluded that Cinnamomum cassia and Azadirachta indica showed remedial or healing effects against nephrotoxicity in rats exposed to TiO2 sublethal doses.