Genome-wide analysis of BMP/GDF family and DAP-seq of YY1 suggest their roles in Cynoglossus semilaevis sexual size dimorphism
文献类型： 外文期刊
作者： Shi, Rui 1 ; Li, Xihong 1 ; Xu, Xiwen 1 ; Chen, Zhangfan 1 ; Zhu, Ying 2 ; Wang, Na 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Funct Lab Marine Sci & Food Prod Proc, Laoshan Lab, Qingdao 266071, Peoples R China
2.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao, Peoples R China
关键词： Sexual size dimorphism; Chinese tongue sole ( Cynoglossus semilaevis ); BMP/GDF family
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）
ISSN： 0141-8130
年卷期： 2023 年 253 卷
页码：
收录情况： SCI
摘要： Sexual size dimorphism (SSD) characterized by different body size between females and males have been re-ported in various animals. Gonadectomy experiments have implied important regulatory roles of the gonad in SSD. Among multiple factors from the gonad, TGF-beta superfamily (especially BMP/GDF family) attracted our interest due to its pleiotropy in growth and reproduction regulations. Thus, whether BMP/GDF family members serve as crucial regulators for SSD was studied in a typically female-biased SSD flatfish named Chinese tongue sole (Cynoglossus semilaevis). Firstly, a total of 26 BMP/GDF family members were identified. The PPI network analysis showed that they may interact with ACVR2a, ACVR2b, ACVR1, BMPR2, SMAD3, BMPR1a, and other proteins. Subsequently, DAP-seq was employed to reveal the binding sites for yin yang 1 (yy1), a transcription factor involved in gonad function and cell growth partly by regulating TGF-beta superfamily. The results revealed that two yy1 homologues yy1a and yy1b in C. semilaevis could regulate Hippo signaling pathway, mTOR signaling pathway, and AMPK signaling pathway. Moreover, BMP/GDF family genes including bmp2, bmp4, bmp5, gdf6a, and gdf6b were important components of Hippo pathway. In future, the crosstalk among yy1a, yy1b, and TGF-beta family would provide more insight into sexual size dimorphism in C. semilaevis.
- 相关文献
作者其他论文 更多>>
-
Establishment, characterization and application of Largemouth bronze gudgeon ( Coreius guichenoti ) fin and skin cell lines in disease resistance
作者：Zhang, Qi;Shi, Yuhong;Liao, Xiaolin;Tian, Hua;Zhang, Qi;Gong, Zhihong;Shi, Rui;Shi, Yuhong;Guo, Chenfei;Wang, Na;Gong, Zhihong
关键词：Largemouth bronze gudgeon(Coreius guichenoti); Cell lines; Skin; Fin; Spring viremia of carp virus (SVCV)
-
Establishment and characterization of cell line from fin of Chinense bahaba (Bahaba taipingensis) and transcriptome analysis of its response to megalocytivirus SKIV-SD strain infection
作者：Gong, Zhihong;Zhang, Qi;Wang, Na;Wang, Lei;Chen, Zhangfan;Chen, Songlin;Gong, Zhihong;Hu, Guobin;Zhang, Qi;Yan, Lin;Yan, Kuoqiu
关键词：Chinese bahaba; Fin; Cell line; BTF; Megalocytivirus
-
The potential role of hippo pathway effector yap1/yap1b in female-biased sexual size dimorphism of Chinese tongue sole (Cynoglossus semilaevis)
作者：Mai, Jiaqi;Mai, Jiaqi;Sun, Yuqi;Li, Xihong;Xu, Wenteng;Chen, Zhangfan;Zhang, Qi;Wang, Jiacheng;Wang, Na;Li, Xihong;Xu, Wenteng;Chen, Zhangfan;Wang, Na;Zhu, Ying
关键词：Cynoglossus semilaevis; Sexual size dimorphism; Hippo signaling pathway; yap1; yap1b
-
Three Copies of zbed1 Specific in Chromosome W Are Essential for Female-Biased Sexual Size Dimorphism in Cynoglossus semilaevis
作者：Sun, Yuqi;Sun, Yuqi;Li, Xihong;Mai, Jiaqi;Xu, Wenteng;Wang, Jiacheng;Zhang, Qi;Wang, Na;Mai, Jiaqi;Wang, Jiacheng;Zhang, Qi
关键词：Cynoglossus semilaevis; sexual size dimorphism; zbed1
-
Characterization of emopamil binding protein (Cs-ebp) reveals its potential role in cholesterol biosynthesis and growth performance of Chinese tongue sole
作者：Chen, Zhangfan;Li, Xihong;Wang, Na;Chen, Songlin;Chen, Zhangfan;Li, Xihong;Cheng, Peng;Mai, Jiaqi;Sun, Yuqi;Wang, Jiacheng;Shi, Rui;Zhang, Qi;Wang, Na;Chen, Songlin;Chen, Zhangfan;Li, Xihong;Cheng, Peng;Mai, Jiaqi;Sun, Yuqi;Wang, Jiacheng;Shi, Rui;Zhang, Qi;Wang, Na;Chen, Songlin;Wang, Na;Chen, Songlin
关键词：Chinese tongue sole; Emopamil-binding protein (EBP); Cholesterol biosynthesis; Sexual size dimorphism; Ovarian development
-
Identification and Functional Analysis of Cynoglossus semilaevis Z-Linked E3 Ubiquitin Ligase rnf34
作者：Li, Lu;Li, Lu;Li, Xihong;Chen, Yadong;Yang, Yingming;Wang, Na;Xu, Wenteng
关键词：Cynoglossus semilaevis; ubiquitin ligase; rnf34; spermatogenesis; siRNA-mediated knockdown
-
Growth arrest and DNA damage-inducible 45 ab gene targeted by miR-20b-5p executes the inflammation and apoptosis by regulating MAPK and NF-κB pathways in black rockfish
作者：Gao, Chengbin;Cai, Xin;Zhu, Ying;Cao, Min;Li, Chao;Gao, Chengbin;Cai, Xin;Ma, Le;Sun, Peng
关键词：Ss _ gadd45ab; Inflammation; Apoptosis; Black rockfish; Regulatory mechanism
