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Immunological effect of Lactic acid bacteria adjuvant on in ovo injection of Newcastle disease vaccine

文献类型： 外文期刊

作者： Ju, Anqi 1 ; Duan, Aoyi 2 ; Zhang, Yingnan 2 ; Liu, Shuang 3 ; Ma, Xin 3 ; Wang, Yongzhi 1 ; Yang, Shubao 2 ; Jin, Lianhai 2 ;

作者机构： 1.Jilin Acad Agr Sci, Jilin 130124, Peoples R China

2.Jilin Med Univ, Jilin 132013, Peoples R China

3.Jilin Agr Univ, Coll Anim Sci & Technol, Jilin 130118, Peoples R China

关键词： Newcastle disease vaccine; Immune adjuvant; Lactic acid bacteria; in ovo injection; Chick

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.3； 五年影响因子：3.5 ）

ISSN： 0378-1135

年卷期： 2023 年 280 卷

页码：

收录情况： SCI

摘要： In ovo immunization of chicken embryos with live vaccines is an effective strategy to protect chickens against various viral pathogens. The immunogenic efficacies of in ovo administration of lactic acid bacteria (LAB) in combination with live Newcastle disease (ND) vaccine were investigated in this study. Four hundred healthy 1 -day-old fertilized specific pathogen-free (SPF) eggs of similar weights were randomly assigned to one of four treatments, with five replicates of each treatment and a total of 20 for each replicate. On day 18.5 of incubation, in ovo injections were given. The treatment groups are as follows: (I) no injection, (II) 0.9% physiological saline injection, (III) ND vaccine injection, and (IV) LAB as an adjuvant for ND vaccine injection. The ND vaccine adjuvanted with LAB significantly increased the daily weight gain, immune organ index, and small intestine histomorphological development in layer chicks while decreasing the feed conversion ratio (FCR). The results suggested that the LAB-adjuvant group significantly affected the relative expression of mucosal mucin protein (mucin-1) and zoccluding small circle protein-1 (ZO-1) (P < 0.05), whereas the relative expression of occludin mRNA was not significantly affected (P > 0.05) compared with the non-injected group. Meanwhile, we indicated that intra-amniotic synbiotic injection significantly maintained the balance of flora (P < 0.05). Compared with the non-injected group, the ND vaccine adjuvanted with the LAB group exhibited significant promotion of the HI and SIgA antibody titers in serum on day 21 (P < 0.05), induction of higher production of cytokines (IL-2, IL-4, IL-6, IFN-gamma) in serum. In summary, in ovo injection of ND vaccine adjuvanted with LAB has a positive impact on the growth performance, immune function, and microbiome of growing chicks.

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