Global analysis of gene expression profiles and gout symptoms in goslings infected with goose astrovirus
文献类型： 外文期刊
作者： Liu, Chenggang 1 ; Li, Linlin 1 ; Dong, Jiawen 1 ; Zhang, Junqin 1 ; Huang, Yunzhen 1 ; Zhai, Qi 1 ; Xiang, Yong 1 ; Jin, Jin 3 ; Huang, Xianshe 3 ; Wang, Gang 1 ; Sun, Minhua 1 ; Liao, Ming 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Hlth, Key Lab Livestock Dis Prevent & Treatment Guangdon, Guangzhou 510640, Peoples R China
2.Minist Agr & Rural Affairs, Key Lab Prevent & Control Avian Influenza & Other, Guangzhou 510640, Peoples R China
3.Shanwei Acad Agr Sci, Shanwei 516699, Peoples R China
4.Minist Agr & Rural Affairs, Sci Observat & Expt Stn Vet Drugs & Diagnost Tech, Guangzhou 510640, Peoples R China
关键词： Goose astrovirus; Gout; Transcriptome analysis; Metabolic networks
期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.3； 五年影响因子：3.5 ）
ISSN： 0378-1135
年卷期： 2023 年 279 卷
页码：
收录情况： SCI
摘要： While blocking inflammation is an effective way to ease the symptoms of gout disease in humans, the treatment and prevention of gout in goslings infected with goose astrovirus (GAstV), a recently emergent condition, remain unclear. In this study, we investigated the reprogramming of the host genes as a result of GAstV infection by combining analysis of the global transcriptome and metabolic network pathways in the kidneys of goslings infected with GAstV. We showed that as GAstV replication increased in vivo, the regulation of key enzymes in the host metabolism progressively increased, flowing metabolites into the purine/pyrimidine biosynthesis pathways. Furthermore, we found that GAstV: 1) inhibits the host oxidation-reduction response by inhibiting the expression of the catalase gene; 2) activates the Toll-like receptor 2 pathway to enhance the immune inflammatory response; and 3) activates the key enzyme in lactic acid synthesis to produce lactate accumulation which inhibits the host's antiviral response, so as to facilitate the replication of the virus itself. This study provided the first insight into the overall metabolic requirements of GAstV for replication in vivo by combining transcriptome with metabolic network pathway information.
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