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Seroprevalence survey of Hepatitis E Virus in Domestic Pigs in Guangdong, China

文献类型： 外文期刊

作者： Liu, Dingyu 1 ; Liu, Baoling 1 ; He, Zhenwen 1 ; Qiao, Changhong 1 ; Luo, Qin 1 ; Chen, Xiangyu 1 ; Wang, Xiaohu 1 ; Xiang, Hua 1 ; Chen, Jing 1 ; Zhang, Pian 1 ; Huang, Yuan 1 ; Wang, Gang 1 ; Tan, Chen 2 ; Cai, Rujian 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Minist Agr & Rural Affairs, Key Lab Livestock Dis Prevent Guangdong Prov, Key Lab Prevent & Control Avian Influenza & Other, Guangzhou 510640, Peoples R China

2.Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China

3.Zhongkai Univ Agr & Engn, Coll Anim Sci & Technol, Guangzhou 510225, Peoples R China

关键词： HEV; zoonoses; pigs; seroprevalence; ELISA

期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.0 ）

ISSN： 2076-2615

年卷期： 2024 年 14 卷 13 期

页码：

收录情况： SCI

摘要： Simple Summary As a zoonotic pathogen, the Hepatitis E virus (HEV) is extensively distributed worldwide. Animal infections are typically asymptomatic, while human infections can result in both acute and chronic viral hepatitis. The transmission pathway is typically a fecal-oral one. Pigs are the primary host of HEV genotype 4 (HEV-4), which primarily causes sporadic infections in China. The aim of this study was to evaluate HEV infection in certain farms in Guangdong, China. Twenty-five pig farms provided 1568 blood samples, of which 902 (902/1568, 57.53%) were positive for anti-HEV IgG. Such a high serum positive rate indicates that pigs in Guangdong are widely exposed to HEV, which is a considerable public health and safety concern.Abstract The Hepatitis E virus (HEV) causes acute and chronic Hepatitis E and is a global public health concern. HEV genotypes 3 (HEV-3) and 4 (HEV-4) are common to humans and animals, and domestic pigs and wild boars have been identified as the main reservoirs. However, limited information is available on the status of HEV infection in pigs, particularly in the Guangdong Province, China. This study aimed to investigate the seroprevalence of HEV in pig farms within the Guangdong Province. A total of 1568 serum samples were collected from 25 farms and tested for anti-HEV IgG antibodies. Enzyme-linked immunosorbent assay (ELISA) results revealed that 57.53% (902/1568) of serum samples from 24 farms (24/25, 96%) were positive for anti-HEV IgG antibodies. Year, season, region, and age were all linked risk factors for HEV in Guangdong, with season and region showing more significant impacts. The results showing a high seroprevalence of HEV confirmed its circulation among domestic pigs in the Guangdong Province, China. The presence of this antibody indicates that HEV infection was or is present on farms, posing a risk of zoonotic transmission of HEV from pigs to exposed workers and from pork or organs to consumption.

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