文献类型： 外文期刊
作者： Hu, Chengjun 1 ; Wu, Zifang 1 ; Huang, Zihao 1 ; Hao, Xiangyu 1 ; Wang, Shuqi 1 ; Deng, Jinping 1 ; Yin, Yulong 3 ; Tan, 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind,Guangdong La, Inst Subtrop Anim Nutr & Feed,Guangdong Prov Key, Guangzhou 510642, Guangdong, Peoples R China
2.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Haikou 571101, Hainan, Peoples R China
3.Chinese Acad Sci, Inst Subtrop Agr, Natl Engn Lab Pollut Control & Waste Utilizat Liv, Changsha 410125, Hunan, Peoples R China
关键词： Angiogenesis; IUGR; Nox2; Placenta; STAT3; VEGF-A
期刊名称：REDOX BIOLOGY （ 影响因子：11.799； 五年影响因子：12.038 ）
ISSN： 2213-2317
年卷期： 2021 年 45 卷
页码：
收录情况： SCI
摘要： Aberrant placental angiogenesis is associated with fetal intrauterine growth restriction (IUGR), but the mechanism underlying abnormal placental angiogenesis remains largely unknown. Here, lower vessel density and higher expression of NADPH oxidases 2 (Nox2) were observed in the placentae for low birth weight (LBW) fetuses versus normal birth weight (NBW) fetuses, with a negative correlation between Nox2 and placental vessel density. Moreover, it was revealed for the first time that Nox2 deficiency facilitates angiogenesis in vitro and in vivo, and vascular endothelial growth factor-A (VEGF-A) has an essential role in Nox2-controlled inhibition of angiogenesis in porcine vascular endothelial cells (PVECs). Mechanistically, Nox2 inhibited phospho-signal transducer and activator of transcription 3 (p-STAT3) in the nucleus by inducing the production of mitochondrial reactive oxygen species (ROS). Dual-luciferase assay confirmed that knockdown of Nox2 reduces the expression of VEGF-A in an STAT3 dependent manner. Our results indicate that Nox2 is a potential target for therapy by increasing VEGF-A expression to promote angiogenesis and serves as a prognostic indicator for fetus with IUGR.
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